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However, the mechanisms underlying how arsenic induces intestinal injury remain unresolved, and the effective means of intervention are very limited. By establishing an acute arsenic exposure animal model, this work shows that arsenic disrupts the mechanical, chemical, immunological, and biological barriers of the intestine, and thereby changes the microenvironment in the gut. We further verify that the administration of fecal microbiota transplantation with a healthy gut microbiome alleviates the intestinal damage induced by arsenic. Intriguingly, by using 16S rRNA sequencing and anaerobic culture, we identify a novel role of gut\u2010derived strain,\n                    <jats:italic>Roseburia intestinalis<\/jats:italic>\n                    , which exhibits significant protection against arsenic\u2010induced intestinal toxicity in mice. By applying non\u2010targeted metabolomics after arsenic exposure, this work further establishes the beneficial effects and the potential metabolites associated with\n                    <jats:italic>Roseburia intestinalis<\/jats:italic>\n                    , including cacodylic acid, carindone, 3\u2010hydroxymelatonin and\n                    <jats:sc>L<\/jats:sc>\n                    \u2010galacto\u20102\u2010heptulose, etc. Transcriptomic analysis reveals that the protective effects of\n                    <jats:italic>Roseburia intestinalis<\/jats:italic>\n                    against arsenic\u2010induced intestinal injury include mainly immune\u2010related pathways. Taken together, these findings highlight that\u00a0supplementation with gut\u2010derived\n                    <jats:italic>Roseburia intestinalis<\/jats:italic>\n                    is an alternative strategy that could be used in the prevention and treatment of arsenic\u2010related intestinal disorders.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511895","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:35:59Z","timestamp":1755671759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel Role of Gut\u2010Derived\n                    <i>Roseburia Intestinalis<\/i>\n                    in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure"],"prefix":"10.1002","volume":"12","author":[{"given":"Lixiao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health School 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