{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:29:41Z","timestamp":1786818581969,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270933"],"award-info":[{"award-number":["32270933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071758"],"award-info":[{"award-number":["82071758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipid droplet accumulation in microglia, microglia\u2010mediated neuroinflammation, and subsequent neuronal damage are hallmark features of high\u2010fat diet (HFD)\u2010induced cognitive impairment. In this analysis, this is proposed that a new molecule feimin (B230219D22Rik in mice) is a key negative regulator of LD accumulation and the inflammatory response in HFD\u2010induced cognitive impairment. To test this hypothesis, BV2 microglia is exposed to palmitic acid (PA) in vitro, mimicking the effects of an HFD. This is found that feimin expression is significantly increased following high\u2010lipid stimulation. Feimin\u2010specific knockdown in BV2 cells led to enhanced LD accumulation, exacerbated inflammatory responses and neuronal apoptosis, whereas feimin overexpression has the opposite effect. Mechanistically, immunoprecipitation (IP) assays revealed that an interaction between feimin and AKT suppressed the AKT\u2013mTOR signaling pathway. To further investigate the role of feimin in vivo, microglial feimin\u2010conditional knockout mice (feimin\n                    <jats:sup>Mic\u2010\/\u2212<\/jats:sup>\n                    ) is developed. In the HFD model, feimin\n                    <jats:sup>Mic\u2010\/\u2212<\/jats:sup>\n                    mice exhibited increased LD accumulation in hippocampal microglia, enhanced inflammation, and neuronal apoptosis, resulting in significant cognitive decline. In conclusion, this findings identified feimin as a key negative regulator of HFD\u2010induced LD accumulation and the microglia\u2010mediated inflammation response, suggesting that it is an attractive therapeutic target for cognitive decline associated with HFDs.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512023","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:52:28Z","timestamp":1760971948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microglial Feimin Alleviates Cognitive Impairment in High\u2010Fat Diet\u2010Fed Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Ran","family":"Gao","sequence":"first","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Xiong","sequence":"additional","affiliation":[{"name":"Headache Center Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Su","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery SanBo Brain Hospital Capital Medical University Beijing 100093 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"},{"name":"Beijing Key Laboratory of Epilepsy Research Department of Brain Institute Center of Epilepsy Beijing Institute for Brain Disorders Sanbo Brain Hospital Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Medical Center &amp; National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaizhi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Qiu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Bian","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery SanBo Brain Hospital Capital Medical University Beijing 100093 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"},{"name":"Beijing Key Laboratory of Epilepsy Research Department of Brain Institute Center of Epilepsy Beijing Institute for Brain Disorders Sanbo Brain Hospital Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-3334","authenticated-orcid":false,"given":"Renxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders Laboratory of Brain Disorders Ministry of Science and Technology Collaborative Innovation Center for Brain Disorders Capital Medical University Beijing 100069 China"},{"name":"Laboratory for Clinical Medicine Capital Medical University Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12009-8"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv151"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.08.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14758"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112579"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.02.025"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-022-00323-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0516-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02446-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03514-5"},{"key":"e_1_2_11_12_1","first-page":"2230","volume":"15","author":"Bouhrara M.","year":"2024","journal-title":"Aging Dis"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0219"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2016-0086"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-014-1490-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.11.018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0566-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.1629"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104415"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07185-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.01.007"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508735"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01175-9"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01176-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04802-y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494759"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0068-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205081"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002247RR"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1741202"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9790-9"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1308-0"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2213984"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00862-y"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20103662\u20106_1"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00179.2013"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27921"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj7813"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.07.005"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15099"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.09.001"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40927-1"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04786-9"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-025-00510-2"},{"key":"e_1_2_11_45_1","first-page":"909","author":"Wang Y.","year":"2010","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00338"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.017"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072036"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666191113101629"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214503"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01324-1"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.04.039"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202009-3381OC"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.623913"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01787-1"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad787"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119385"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511002868"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1051100"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.08.037"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.010"},{"key":"e_1_2_11_62_1","first-page":"108","volume":"29","author":"Du S.","year":"2023","journal-title":"Mol Med"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00676-9"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04374-3"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe3947"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01456-2017"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.02.040"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01129-y"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202512023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:11:41Z","timestamp":1786817501000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202512023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":68,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/advs.202512023"],"URL":"https:\/\/doi.org\/10.1002\/advs.202512023","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"2025-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12023"}}