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Polyethylene terephthalate (PET) is a major plastic contaminant detected in food and beverages. However, the chronic effects of environmentally relevant, physically abraded PET\u2010MPs on health, on the liver, remain elusive. This study investigates the hepatotoxicity of the PET\u2010MPs following long\u2010term exposure, with a focus on the gut\u2013liver axis interactions and transcriptomic responses. Male mice are exposed to PET\u2010MPs (5\u00a0mg\u00a0week\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) from 5 to 34 weeks of age. Environmentally mimetic PET particles are prepared by grinding plastic bottles. Prolonged exposure to MPs for 29 weeks led to increased adiposity and obesity. The mice exposed to PET\u2010MPs developed hepatomegaly, steatosis, and early\u2010stage fibrosis. Transcriptome data revealed the downregulation of genes involved in mitochondrial energy metabolism and the upregulation of lipid droplet and fibrotic pathway genes. Gut microbiota is also significantly changed, with a decrease in\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    and\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    , which maintain gut homeostasis. Disruption of bile acid metabolism and fecal color change further indicated impairment of the gut\u2013liver axis. These findings provide new toxicological insights and emphasize the requirement to reassess the public health risks posed by long\u2010term MPs ingestion.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512030","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:12:55Z","timestamp":1761163975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Chronic PET\u2010Microplastic Exposure: Disruption of Gut\u2013Liver Homeostasis and Risk of Hepatic Steatosis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6154-9214","authenticated-orcid":false,"given":"Surye","family":"Park","sequence":"first","affiliation":[{"name":"Department of Applied Biosciences Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-7542","authenticated-orcid":false,"given":"Min\u2010Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Biosciences Kyungpook National University  Daegu 41566 Republic of Korea"},{"name":"NGS Core Facility Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-9787","authenticated-orcid":false,"given":"Jae\u2010Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Applied Biosciences Kyungpook National University  Daegu 41566 Republic of Korea"},{"name":"NGS Core Facility Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-8280","authenticated-orcid":false,"given":"Eunsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development Pusan National University  Busan 46241 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-3991","authenticated-orcid":false,"given":"Myeongjoo","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology School of Medicine Kangwon National University  Chuncheon 24341 Republic of Korea"},{"name":"Brain Health Research Laboratory Institute of Medical Science Kangwon National University College of Medicine  Chuncheon 24341 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-3521","authenticated-orcid":false,"given":"Seungjun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Biosciences Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107273"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c04706"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1199519"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282080"},{"key":"e_1_2_9_8_1","first-page":"185","volume":"14","author":"Rector R. 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