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This study introduces a multifunctional nitric oxide (NO)\u2010driven hollow gold Janus nanomotor (HAM) designed to promote tumor blood vessel normalization and increase T\u2010cell infiltration, thereby enhancing the immune response against tumors. It is revealed that self\u2010generated NO facilitates the penetration of HAM into tumors and increases pericyte coverage of blood vessels, thereby enhancing intratumoral T\u2010cell infiltration. HAMs then induce and capture whole\u2010tumor antigens to enhance T\u2010cell activation as an in situ cancer vaccine. Additionally, vascular endothelial growth factor C (VEGFC) is used in combination to induce functional lymphangiogenesis, aiding dendritic cell (DC) migration of tumor\u2010draining lymph nodes (TDLNs). In B16F10 mice, the proportion of tumor\u2010infiltrating T cells increased from 0.5% to 27.4% while that of mature DCs in TDLNs increased from 4.3% to 16.6%, markedly improving tumor\u2010killing effects. Similar outcomes are observed in 4T1 tumor\u2010bearing mice. Collectively, this study highlights the importance of paving the way for intratumoral infiltration of immune cells via nanomotors, which provides a novel idea for enhancing antitumor immunotherapeutic effects.<\/jats:p>","DOI":"10.1002\/advs.202512090","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:43:03Z","timestamp":1757328183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["NO\u2010Driven Janus Nanomotor Enhances T\u2010Cell Infiltration by Reconstructing Tumor\u2010Associated Blood and Lymphatic Vessels"],"prefix":"10.1002","volume":"12","author":[{"given":"Qingping","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics NMPA Key Laboratory for Technology Research and Evaluation of Drug Products Key Laboratory of Chemical Biology (Ministry of Education) State 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