{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:45:27Z","timestamp":1792421127504,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203194"],"award-info":[{"award-number":["52203194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2254900"],"award-info":[{"award-number":["20DZ2254900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The complex tumor microenvironment (TME) remains a major barrier to effective breast cancer therapy. A modular nanoplatform capable of sequentially reprogramming the TME through cascade actions and responsive therapeutic functions is developed to enhance breast cancer immunotherapy. A hybrid nanoparticle (MCC) containing manganese dioxide (MnO\n                    <jats:sub>2<\/jats:sub>\n                    ), calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    ), and chlorin e6 (Ce6) is synthesized and subsequently camouflaged with a tumor cell membrane. Surface conjugation of a PD\u2010L1 antibody (\u03b1P) is then achieved via a glutathione (GSH)\u2010responsive fragment, resulting in the formation of an integrated nanoplatform MCC@TM\u2010\u03b1P. Through dual\u2010targeting mechanisms involving the tumor cell membrane and the PD\u2010L1 antibody, MCC@TM\u2010\u03b1P achieves efficient enrichment at tumor sites. MCC@TM\u2010\u03b1P alleviates hypoxia by generating O\n                    <jats:sub>2<\/jats:sub>\n                    from CaO\n                    <jats:sub>2<\/jats:sub>\n                    in the acidic TME and scavenges GSH via the MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated Fenton\u2010like reaction, thereby markedly amplifying the sonodynamic efficacy of Ce6. The combined effects of sonodynamic therapy and chemodynamic therapy ablate tumors and reprogram the immunosuppressive TME. Upon cleavage of the GSH\u2010responsive fragment by intratumoral GSH, MCC@TM\u2010\u03b1P releases the PD\u2010L1 antibody, eliciting a robust immune response that eradicates metastatic tumors. In murine breast cancer models, this therapeutic strategy enhances tumor infiltration by effector T cells and suppresses metastatic progression. By sequentially decoupling the immunosuppressive mechanisms, this study provides a programmable approach to potentiate immunotherapy and overcome TME\u2010driven resistance.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512135","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:34:31Z","timestamp":1761309271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic\u2010Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Henan Provincial People's Hospital Zhengzhou University People's Hospital Henan University People's Hospital  Zhengzhou Henan 450003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheming","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-3202","authenticated-orcid":false,"given":"Jingchao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Henan Provincial People's Hospital Zhengzhou University People's Hospital Henan University People's Hospital  Zhengzhou Henan 450003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00468-9"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00551-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00529-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01141-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00714-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103836"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.09.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215467"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39901-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53646-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404375"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01026-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00573-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00552-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.05.025"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301928"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.022"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00699-x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00840-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.021"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh8342"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29539-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00699-x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303261"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312169"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401495"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304845"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206200"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305459"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp9071"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201734"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30306-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206765"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304845"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305382"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304328"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403158"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307278"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207200"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01132-2"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00920-9"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215307"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35348-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29366-6"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn0327"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh5548"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07767-5"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211130"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303059"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204365"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402516"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307143"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c00881"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202512135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:01:05Z","timestamp":1774270865000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202512135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202512135"],"URL":"https:\/\/doi.org\/10.1002\/advs.202512135","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12135"}}