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Combining chronic multisite electrophysiology, behavioral tracking, and machine learning in PD models, a hierarchical disintegration of oscillatory dynamics across the olfactory network that mechanistically drives disease progression is uncovered. Early\u2010stage PD mice are identified to show attenuated odor discrimination, accompanied by hyperexcitability of mitral\/tufted (M\/T) cells. Causally linking these deficits, aberrant gamma oscillation in the cross\u2010olfactory network is identified as a causal factor underlying olfactory deficits. Notably, cognitive impairment emerged at later stages, correlating with abnormal theta oscillations in the cross\u2010olfactory network. Pharmacological modulation of the olfactory bulb (OB)\u2010lateral entorhinal cortex (LEC) pathway ameliorated cognitive deficits and restored cross\u2010network theta oscillation. Collectively, the findings establish cross\u2010olfactory network oscillations as dual diagnostic and therapeutic targets for PD cognitive impairment, providing a mechanism\u2010guided framework for early intervention.<\/jats:p>","DOI":"10.1002\/advs.202512183","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:42:33Z","timestamp":1764938553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olfactory\u2010to\u2010Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency\u2010Specific Oscillatory Decoupling"],"prefix":"10.1002","volume":"13","author":[{"given":"Shuaishuai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology School of Basic Medical Sciences Nanjing Medical University  Nanjing 211166 China"},{"name":"Jiangsu Province Innovation center for Brain\u2010Inspired intelligence technology  Nanjing 210029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhishen","family":"Cai","sequence":"additional","affiliation":[{"name":"Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of Education  Nanjing 211166 China"},{"name":"Key Laboratory of Cardiovascular &amp; 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