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While targeted restoration of aberrant ciliary motion can theoretically rescue left\u2010right patterning defects, existing manipulation strategies lack the non\u2010invasiveness, micron\u2010scale precision, and spatiotemporal programmability required for developmental interventions. Here, a multifunctional Opto\u2010Bio\u2010Hydrodynamic platform is presented to modulate ciliary motion with the programmable near\u2010infrared light for instructing cardiac left\u2010right asymmetry development in a spatiotemporally controlled manner. By the real\u2010time modulation of a 1064\u2010nm light beam, a direct optical trapping is demonstrated for the motile cilia, while uniform synchronization of ciliary beating is achieved through indirect optical regulation. Consequently, a coordinated ciliary rotational pattern triggers an enhanced recirculating flow, under which the methylcellulose\u2010induced cardiogenesis abnormality is rescued in a fully controlled manner. By establishing mechanistic links among optically tuned ciliary dynamics, flow\u2010mediated signaling, and organ asymmetry, this proposed strategy provides valuable insights into congenital heart defects and offers a promising biomedical platform for developmental bioengineering and mechanobiological therapeutics.<\/jats:p>","DOI":"10.1002\/advs.202512368","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:07:25Z","timestamp":1755511645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Opto\u2010Bio\u2010Hydrodynamic Platform for Instructing Cardiac Left\u2010Right Asymmetry Development"],"prefix":"10.1002","volume":"12","author":[{"given":"Haifeng","family":"Qin","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of Nanophotonics College of Physics &amp; Optoelectronic Engineering Jinan University  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