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Dictamni Cortex (BXP), a traditional Chinese medicine (TCM), has demonstrated potential in alleviating psoriasis; however, its clinical application is hampered by poor water solubility and low bioavailability. It is developed infinite coordination polymer nanoparticles (BXP\u2010Fe (III) ICPs, NB), which enhance the aqueous solubility by 95\u2010fold and bioavailability of BXP, exerting therapeutic effect through efficient transdermal delivery. NB significantly suppresses keratinocyte hyperproliferation, inflammation, and oxidative stress in both M5 (a cocktail of cytokines)\u2010treated human epidermal keratinocytes (HEKa) cells and imiquimod (IMQ)\u2010induced psoriatic mice. Nascent proteomics identified heat shock protein 90 alpha family class B member 1 (HSP90AB1) as a key target downregulated by NB. It is further revealed that NB suppresses HSP90AB1 transcription by inhibiting its activator, CCCTC\u2010binding factor (CTCF), and disrupts the HSP90AB1\u2010CDC37 (cell division cycle 37, the co\u2010chaperone) chaperone complex, thereby inactivating the pivotal client proteins STAT3 and Akt. Notably, NB demonstrated superior therapeutic efficacy over the canonical HSP90 inhibitor AUY922. This study highlights NB as a promising topical nanotherapy for psoriasis, integrating TCM with modern nanotechnology to overcome pharmacological limitations. The underlying molecular mechanisms of NB are elucidated through the CTCF\u2010HSP90AB1\u2010STAT3 axis.<\/jats:p>","DOI":"10.1002\/advs.202512422","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:56:01Z","timestamp":1760972161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Self\u2010Assembled\n                    <i>Dictamni Cortex<\/i>\n                    Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhengyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 710061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology The 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