{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:55:47Z","timestamp":1793019347643,"version":"4.5.0"},"reference-count":104,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572765"],"award-info":[{"award-number":["82572765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802119"],"award-info":[{"award-number":["81802119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172452"],"award-info":[{"award-number":["82172452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572693"],"award-info":[{"award-number":["82572693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502958"],"award-info":[{"award-number":["82502958"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272556"],"award-info":[{"award-number":["82272556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472395"],"award-info":[{"award-number":["82472395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404159"],"award-info":[{"award-number":["82404159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20251831"],"award-info":[{"award-number":["BK20251831"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoblast dysfunction contributes to systemic metabolic disorders by inducing insulin resistance (IR), a key factor in metabolic\u2010related fibrosis. Therefore, the axis of osteoblast dysfunction, IR, and multi\u2010organ fibrosis represents a crucial pathological pathway. This study revealed that the deletion of Ubiquitin Specific Peptidase 26\u00a0(USP26) in osteoblasts leads to decreased bone formation along with multi\u2010organ fibrosis associated with IR. Mechanistically, the loss of USP26 decreases histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH\u2010Type Splicing Regulatory Protein (KSRP), resulting in decreased expression of KSRP and decreased alternative splicing of follistatin\u2010like protein 1 (FSTL1) mRNA by KSRP. Elevated FSTL1 expression causes IR and high blood glucose levels, which leads to advanced glycation end\u2010product (AGE)\u00a0accumulation in the blood and multi\u2010organ fibrosis. Activation of the USP26 pathway, specifically in osteoblasts, through extracellular vesicle\u2010based bone\u2010targeting drugs or mechanical loading can effectively prevent multi\u2010organ fibrosis induced by IR. This study uncovered a causal relationship between skeletal degeneration and metabolism\u2010related fibrosis, and highlights osteoblastic USP26 as a promising therapeutic target for addressing multi\u2010organ fibrosis associated with IR.<\/jats:p>","DOI":"10.1002\/advs.202512424","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:42:38Z","timestamp":1766166158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activating the Osteoblastic USP26 Pathway Alleviates Multi\u2010Organ Fibrosis by Decreasing Insulin Resistance"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiyuan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"You","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Kunshan Hospital of Chinese Medicine Affiliated Hospital of Yangzhou University  Suzhou Jiangsu China"},{"name":"Institute of Traumatology and Orthopedics Kunshan Hospital of Chinese Medicine Affiliated Hospital of Yangzhou University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Kunshan Hospital of Chinese Medicine Affiliated Hospital of Yangzhou University  Suzhou Jiangsu China"},{"name":"Institute of Traumatology and Orthopedics Kunshan Hospital of Chinese Medicine Affiliated Hospital of Yangzhou University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-4685","authenticated-orcid":false,"given":"Changwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32542-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2020.03.102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01501-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110289"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00396-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050797"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01543-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1776"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.12.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320313497817"},{"key":"e_1_2_9_13_1","article-title":"Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet\u2010Induced Obese Mice","author":"Musale V.","year":"2023","journal-title":"Biorxiv"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170175"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00231"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16039"},{"key":"e_1_2_9_17_1","first-page":"802","article-title":"Pipeline of New Drug Treatment for Non\u2010Alcoholic Fatty Liver Disease\/Metabolic Dysfunction\u2010Associated Steatotic Liver Disease","volume":"12","author":"Hu Y.","year":"2024","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.147"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.11.015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12581"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13639"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.785117"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.157"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0147"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030480"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0246-y"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114308"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0019-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34869-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2022.100433"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01257-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00904-x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406428"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00424-1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2020.05.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147546"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2304492120"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.112605"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00335-7"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00807-x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2023.0240"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090042"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03750-4"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101694"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00142-4"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/752519"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.05.001"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10934"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121878"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00610-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02162-6"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-4226"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.031"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02008-9"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01259-0"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11890"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219748110"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42150"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.08.009"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0040-5"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26576-1_2"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301202"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6IB00070C"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.12.005"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1445049"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51155-6"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2024-00025"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328129"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-023-01493-0"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21697"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_16"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010349"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111335"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063028"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19148677"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15708"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325150"},{"key":"e_1_2_9_79_1","article-title":"Follistatin\u2010Like 1 as a Novel Adipomyokine Related to Insulin Resistance and Physical Activity","volume":"105","author":"Xu X.","year":"2020","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004486"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S302"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-025-00063-4"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041231"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02360-1"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i6.860"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0763-7"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.72977"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050438"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185862"},{"key":"e_1_2_9_90_1","article-title":"Treatment With Small Molecule Inhibitors of Advanced Glycation End\u2010Products Formation and Advanced Glycation End\u2010Products\u2010Mediated Collagen Cross\u2010Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice","volume":"12","author":"Li Y.","year":"2023","journal-title":"Journal of the American Heart Association"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.166044"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2024.02.007"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0460-2"},{"key":"e_1_2_9_94_1","first-page":"221","article-title":"Advanced Glycation End\u2010Products and Receptor for Advanced Glycation End\u2010Products Expression in Patients With Idiopathic Pulmonary Fibrosis and NSIP","volume":"7","author":"Kyung S. Y.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.05.145"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3598715"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313901"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.757068"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1111-y"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15372"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13440"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110262"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03620-1"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00064"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00903-7"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202512424","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:42:30Z","timestamp":1783014150000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202512424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":104,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/advs.202512424"],"URL":"https:\/\/doi.org\/10.1002\/advs.202512424","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12424"}}