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Immune reprogramming is a promising strategy, but current implants rely predominantly on passive and static modulation of macrophages. Dynamically reprogramming macrophages based on physiological states to switch between antibacterial and tissue\u2010healing functions remains a challenge. Here, a novel polyetheretherketone (PEEK) surface is developed sequentially modified through sulfonation, hydrogen plasma immersion ion implantation (H\u2010PIII), and magnesium plasma immersion ion implantation (Mg\u2010PIII) to fabricate a Mg\u2010H\u2010SPEEK composite with a graphene\u2010like matrix embedded with MgO. This film simultaneously enables sustained Mg\n                    <jats:sup>2<\/jats:sup>\n                    \u207a release with near\u2010infrared (NIR) photothermal responsiveness for on\u2010demand immunomodulation. Under normal conditions, Mg\n                    <jats:sup>2<\/jats:sup>\n                    \u207a released from Mg\u2010H\u2010SPEEK can promote macrophage reprogramming toward the M2 phenotype through the TNF, JAK\u2010STAT, NF\u2010\u03baB, and IL\u201017 pathways to accelerate soft tissue repair. Upon NIR light exposure, photothermal stimulation enhances the expression of the Traf1 in macrophages via the TNF, FoxO, and JAK\u2010STAT signaling pathways to drive M1 reprogramming for bacterial phagocytosis. The dual\u2010mode system synergizes hyperthermia and immune phagocytosis for infection resistance while preserving pro\u2010healing functions, offering a smart strategy for percutaneous implants.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512592","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:25:11Z","timestamp":1762266311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Near\u2010Infrared Switch\u2010Driven Macrophage Dynamically Reprogramming for Anti\u2010Infection and Tissue Healing on Polyetheretherketone Implants"],"prefix":"10.1002","volume":"12","author":[{"given":"Yinghao","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou 310024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibing","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zou","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"},{"name":"School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou 310024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9607-496X","authenticated-orcid":false,"given":"Xiaochun","family":"Peng","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01552-y"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-0204-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198705000-00007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-016-5731-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.09.017"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2021.100162"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14245526"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics9100642"},{"key":"e_1_2_8_6_3","first-page":"116","volume":"3","author":"Sun C.","year":"2022","journal-title":"Biomater. 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