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In this study, 16S rRNA sequencing is employed to uncover differences in the abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    within the vaginal microbiota between individuals with cervical cancer and those with healthy cervixes. The research further identifies that the metabolite of\n                    <jats:italic>Lactobacillus crispatus<\/jats:italic>\n                    can induce ferroptosis in cervical cancer cells. This conclusion is reached through targeted bacterial culture, patient\u2010derived organoids (PDO) and single\u2010cell RNA sequencing. Erucic acid, identified as a primary metabolite via untargeted metabolomics, acts as a ligand for PPAR\u03b4 receptor. It has the capacity to activate PPAR\u03b4 pathway and subsequently trigger downstream fatty acid oxidation (FAO). Excessive enhancement of FAO can generate large amounts of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010, known as ROS. Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of\n                    <jats:italic>L. crispatus<\/jats:italic>\n                    , erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR\u2010\u03b4 pathway. This activation leads to fatty acid oxidation, release ROS, and ultimately induces ferroptosis. Therefore,\n                    <jats:italic>L. crispatus<\/jats:italic>\n                    and erucic acid show potential as novel adjuvant therapeutic agents in the treatment of cervical cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512599","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:29:22Z","timestamp":1760408962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Erucic Acid, Derived by\n                    <i>Lactobacillus Crispatus<\/i>\n                    , Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR\u2010\u03b4 Signaling Pathway"],"prefix":"10.1002","volume":"12","author":[{"given":"Qianwei","family":"Zhen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  107 Wenhua Xi Road Jinan Shandong Province 250012 China"},{"name":"Shandong Key Laboratory of 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Hospital of Shandong University  107 Wenhua Xi Road Jinan Shandong Province 250012 China"},{"name":"Shandong Key Laboratory of Reproductive Health and Birth Defects Prevention and Control 44 Wenhua Xi Road Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  107 Wenhua Xi Road Jinan Shandong Province 250012 China"},{"name":"Shandong Key Laboratory of Reproductive Health and Birth Defects Prevention and Control 44 Wenhua Xi Road Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  44 Wenhua Xi Road Jinan Shandong Province 250012 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