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However, current clinical formulations and composites, while demonstrating improvements in certain areas, often fail to comprehensively address challenges, including rheological injectability, mechanical stability, interconnected porosity, degradability, and bioactivity. To overcome limitations, a novel bone cement comprising linear polyhydroxy PEGylated poly(glycerol sebacate) (L\u2010PEGS) and calcium phosphate cement (CPC) is developed. The incorporation of L\u2010PEGS enhances injectability and reinforces the mechanical weakness of CPC, resulting in improvement in compressive strength (increased by 16.7 folds) and fatigue resistance (1000 cycles). Owing to linear polyhydroxy backbone, L\u2010PEGS initiates self\u2010reinforcing cross\u2010linking reaction synchronized with the hydration of CPC into hydroxyapatite. This hydration reinforcement is mediated by its abundant hydroxyl groups and high water absorption capacity, which accelerate hydration kinetics. Concurrently, the cross\u2010linking reaction generates in situ carbon dioxide, resulting in porous microarchitecture that facilitates hydration process, enhances cement degradability, and promotes nutrient exchange and new bone ingrowth. In vitro and vivo studies confirmed that L\u2010PEGS\/CPC substantially enhances osteogenesis compared to clinical materials. Collectively, this injectable, hydration\u2010driven, and self\u2010reinforcing bone cement offers comprehensive solution to the challenges in current bone graft materials, holding promise for clinical bone repair.<\/jats:p>","DOI":"10.1002\/advs.202512723","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T04:06:24Z","timestamp":1763352384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Injectable and In Situ Hydration\u2010Reinforced Hybrid Bone Cements for Accelerated Bone Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Xing","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 P. R. 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