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However, several studies have highlighted significant challenges posed by low drug transfer efficiency and immediate lumen loss due to elastic recoil. Herein, we propose a bioabsorbable endovascular adhesive tape (BEAT) platform that can realize robust adhesion and complete transfer after balloon inflation, enabling efficient endoluminal drug delivery while providing temporary radial support against elastic recoil. This BEAT coated balloon contains sprayable Janus coating layers of crosslinked drug\u2010eluting polyelectrolyte complexes (PECs) and poly(thioctic acid) (PTA) adhesive layer. Notably, the poly (L\u2010lysine\u2010co\u2010L\u2010leucine)\u2010poly (acrylic acid) PECs (PKL\u2010PAA, KLA) exhibit exceptional anti\u2010coagulation properties and selective endothelial cell adhesion behavior. Moreover, the hydrophobic interaction and photo\u2010controllable crosslinking of KLA PECs enable flexible mechanical tunability (0.74\u201310.9\u00a0MPa), robust swelling resistance, and enzyme\u2010responsive biodegradability, thus guaranteeing temporary mechanical reinforcement for blood vessels with efficient drug delivery. In a rat abdominal aorta injury model, this BEAT coated balloon demonstrates intact transfer with mechanical compliance to the vessel and effectively attenuates neointimal hyperplasia. This BEAT platform offers a promising perspective for the development of DCBs in vascular interventions.<\/jats:p>","DOI":"10.1002\/advs.202512857","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:14:16Z","timestamp":1770732856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-8702","authenticated-orcid":false,"given":"Jiarong","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Transvascular Implantation Devices Department of Cardiology The Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou P. R. 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