{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:46:43Z","timestamp":1788288403405,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms behind dystonia are still one of the crucial unsolved research topics.\n                    <jats:italic>Gnal<\/jats:italic>\n                    haploinsufficient (\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    ) mice are used as a model of DTY25 dystonia to investigate the mechanistic relationship between gut microbiota and dystonia. The present study unveiled\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice exhibit significant motor deficits of dystonia, along with a marked gut microbiota dysbiosis. Analysis of the gut microbiota composition and function reveals that\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice have decreased butyrate\u2010producing bacteria abundance (such as\n                    <jats:italic>Lachnospiraceae_NK4A136<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    , and\n                    <jats:italic>Butyricicoccus<\/jats:italic>\n                    ) and disrupted butanoate metabolism. The targeted metabolomics analysis indicates that the\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice exhibit decreased butyrate levels in feces and serum. The colonization of antibiotic\u2010treated wild\u2010type mice with fecal microbiota from\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice is sufficient to induce motor deficit symptoms. Oral administration of sodium butyrate ameliorated motor deficits in the\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mouse model of DYT25 dystonia. Striatal single\u2010nucleus RNA sequencing reveals cell\u2010type\u2010specific gene expression changes, suggesting that butyrate modulates neurotransmitter pathways, particularly GABA signaling. This is confirmed by restored striatal GABA levels after butyrate supplementation. In sum, gut microbiome contributes to dystonia pathogenesis, and butyrate supplementation alleviates the motor deficits of dystonia in\n                    <jats:italic>Gnal<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice.\n                  <\/jats:p>","DOI":"10.1002\/advs.202512942","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T01:55:37Z","timestamp":1765590937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Gut Microbiota Regulates Motor Deficits via Butyrate in a\n                    <i>Gnal<\/i>\n                    <sup>+\/\u2212<\/sup>\n                    Mouse Model of DYT25 Dystonia"],"prefix":"10.1002","volume":"13","author":[{"given":"Jingya","family":"Guo","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Gook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food Engineering and Solar Salt Research Center Mokpo National University  Muangun 58554 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlun","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"},{"name":"Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety) The Ministry of Agriculture and Rural Affairs of the PR China Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-2893","authenticated-orcid":false,"given":"Tao","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"},{"name":"Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety) The Ministry of Agriculture and Rural Affairs of the PR China Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1435","volume":"28","author":"Dystonias S. 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