{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:34:07Z","timestamp":1782311647742,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increasing prevalence of emerging infectious diseases highlights the urgent need for broad\u2010spectrum antiviral therapeutics. Here, the discovery of SB2960, a small molecule, is reported that promotes stress granule (SG) formation and exhibits potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. Target identification studies reveal that SB2960 engages receptor for activated protein C kinase 1 (RACK1), a key regulator of SG dynamics. Integrated transcriptomic and proteomic analyses further demonstrate that SB2960 alters the composition of SG and modulates the expression of antiviral genes. These findings establish SB2960 as a promising host\u2010directed broad\u2010spectrum antiviral agent and a valuable probe for investigating SG biology in the context of viral infection.<\/jats:p>","DOI":"10.1002\/advs.202512972","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:05:02Z","timestamp":1768395902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Host\u2010Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4720-2033","authenticated-orcid":false,"given":"Wan Gi","family":"Byun","sequence":"first","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2999-1260","authenticated-orcid":false,"given":"Sumin","family":"Son","sequence":"additional","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinAh","family":"Lee","sequence":"additional","affiliation":[{"name":"Zoonotic Virus Laboratory Institut Pasteur Korea  Seongnam 13488 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minha","family":"Lee","sequence":"additional","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-5545","authenticated-orcid":false,"given":"Meehyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Zoonotic Virus Laboratory Institut Pasteur Korea  Seongnam 13488 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songrui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies, Peking\u2010Tsinghua Center for Life Sciences Peking University  Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"SPARK Biopharma, Inc  Seoul 08791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Vaithegi","sequence":"additional","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Kwon","sequence":"additional","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Chemical Biology Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Zoonotic Virus Laboratory Institut Pasteur Korea  Seongnam 13488 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawon","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Chemical Biology Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies, Peking\u2010Tsinghua Center for Life Sciences Peking University  Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungtaek","family":"Kim","sequence":"additional","affiliation":[{"name":"Zoonotic Virus Laboratory Institut Pasteur Korea  Seongnam 13488 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-1433","authenticated-orcid":false,"given":"Seung Bum","family":"Park","sequence":"additional","affiliation":[{"name":"CRI Center for Chemical Proteomics, Department of Chemistry Seoul National University  Seoul 08826 South Korea"},{"name":"SPARK Biopharma, Inc  Seoul 08791 South Korea"},{"name":"Department of Biophysics and Chemical Biology Seoul National University  Seoul 08826 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00198-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-025-01189-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2614"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.04.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00468-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.05.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.10.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170236"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.162"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00168-19"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.05.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.05.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03873-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2061"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01091-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.03.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC05508A"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja508343a"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01317"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1809592"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abq0837"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01215"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.63"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00489"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118542"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201200609"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC03238A"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.156"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3593"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.204"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.12.026"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.041"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2020.03.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00596-21"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012097"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1215-y"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43194-2"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf6548"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.05.017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300963"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202401101"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.01.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28863"},{"key":"e_1_2_9_47_1","volume-title":"Virology Methods Manual","author":"Hierholzer J. C.","year":"1996"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.000835"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202512972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202512972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:41:11Z","timestamp":1773304871000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202512972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/advs.202512972"],"URL":"https:\/\/doi.org\/10.1002\/advs.202512972","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12972"}}