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Nevertheless, reliable and cost\u2010effective technologies for resource recovery from refractory nitrogenous organic wastewaters (NOWs) are very scarce. Therefore, this study proposes an innovative strategy that couples the bioremediation of NOWs with sustainable production of polyhydroxybutyrate (PHB). Specifically, this study employs the newly discovered\n                    <jats:italic>Paracoccus<\/jats:italic>\n                    sp. ZQW\u20101 as a \u201csustainable cell factory\u201d, which exhibits outstanding PHB production capabilities using N\u2010methylpyrrolidone (NMP) as the specific nitrogen source. Ingeniously, the selective pressure of NMP eliminates the sterilization requirement in PHB biorefinery processes. Capitalizing on this advantage, the conceptual demonstration of simultaneous non\u2010sterile PHB production (7.71\u2009g\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and steady\u2010state wastewater depuration is successfully conducted in a 3\u2010L bioreactor. More encouragingly, this paradigm has been successfully applied to the valorization of diverse NOWs (e.g., pyridine and N, N\u2010dimethylformamide), demonstrating its general applicability. Therefore, this study provides a valuable reference for upcycling other NOWs (e.g., aziridine, acridine, pyrrole, and indole). Additionally, life\u2010cycle assessment and techno\u2010economic analysis validate the environmental and economic sustainability of this biorefinery process. Overall, this study proposes an innovative biorefinery strategy and offers a forward\u2010looking trajectory for sustainable wastewater valorization.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513035","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:19:57Z","timestamp":1763129997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N\u2010Cycling Bacterium"],"prefix":"10.1002","volume":"13","author":[{"given":"Ziqian","family":"Wang","sequence":"first","affiliation":[{"name":"College of Resources and Environmental Sciences Nanjing Agricultural University  Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Du","sequence":"additional","affiliation":[{"name":"College of Resources and Environmental Sciences Nanjing Agricultural University  Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Resources and Environmental Sciences Nanjing Agricultural University  Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-0376","authenticated-orcid":false,"given":"Dahu","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Resources and Environmental Sciences Nanjing Agricultural University  Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-024-01423-6"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57720-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255183"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-018-0187-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/528029a"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-024-01478-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44221-024-00307-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.052"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01195-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01248-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-023-01252-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-024-01406-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-023-01233-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2024.121778"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2025.104161"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg4520"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29218-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6159"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2024.131926"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17223-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2024.121754"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2024.121168"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2166\/wst.2015.031"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jwpe.2023.104327"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.122185"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibiod.2014.04.022"},{"key":"e_1_2_8_27_1","volume":"84","author":"Sol\u00eds\u2010Gonz\u00e1lez Claudia J.","year":"2017","journal-title":"Appl. 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