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Herein,\n                    <jats:italic>Halomonas<\/jats:italic>\n                    TD (salt\u2010resistant) was adaptively evolved into TD80, which efficiently uses acetate; its\n                    <jats:italic>aceE<\/jats:italic>\n                    gene mutation (encoding pyruvate dehydrogenase) drives acetate utilization. Subsequently, different biosynthesis pathways in TD80 enabled high yields of poly\u20103\u2010hydroxybutyrate (PHB), poly\u20103\u2010hydroxybutyrate\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u20104\u2010hydroxybutyrate (P34HB), 3\u2010hydroxybutyrate (3HB), violacein, ectoine, 1,3\u2010diaminopropane (1,3\u2010DAP) and superoxide dismutase (SOD), respectively. Moreover, 26.0 g L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ectoine and 29.6 g L\n                    <jats:sup>\u22121<\/jats:sup>\n                    PHB can be achieved by recombinant TD80 strains during fed\u2010batch studies. Finally, a non\u2010canonical pathway was designed to recycle the excess malonyl\u2010CoA into PHB. The resultant PHB content in fed\u2010batch study was increased from 60 wt% to 80 wt%. Moreover, co\u2010producing ectoine and PHB could further boost the CCR of CDE\u2010to\u2010product up to 53.7 mol%, which exemplified promising potential for biohybrid CO\n                    <jats:sub>2<\/jats:sub>\n                    upcycling involved in carbon capture and utilization system. Furthermore, TD80 was engineered to grow on formate only aiming to achieve the full use of CDE. The establishment of technology and economy assessment (TEA) confirmed the\n                    <jats:italic>Halomonas<\/jats:italic>\n                    \u2010based platform\u2019s efficiency and economic viability for carbon footprint reduction.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513060","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:26:21Z","timestamp":1761308781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Efficient CO\n                    <sub>2<\/sub>\n                    \u2010Upcycling Platform Based on Engineered\n                    <i>Halomonas<\/i>\n                    TD with Enhanced Acetate\u2010Utilizing Capacity via Adaptive Laboratory Evolution"],"prefix":"10.1002","volume":"13","author":[{"given":"Chi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biology and Biological Engineering South China University of Technology  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering South China University of Technology  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering South China University of Technology  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Xi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering South China University of Technology  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Xin","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering South China University of Technology  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Chun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Food and Drug Department Liaoning Agricultural Vocational and Technical College  Yingkou 115009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Tai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui\u2010Zhe","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Xiang","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Science China University of Geosciences  Beijing 100083 China"},{"name":"CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Science  Shenzhen 518055 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Situ","sequence":"additional","affiliation":[{"name":"Guangzhou Medpha Biotechnology Co., Ltd.  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