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They uniquely bridge the ionic and electronic domains while offering mechanical compliance, biocompatibility, and high signal amplification. These characteristics make them especially advantageous for applications requiring stable, long\u2010term integration with soft, deformable, and dynamic biological tissues. This review provides a comprehensive summary of recent progress in the design, fabrication, and application of OECTs for biological integration. It begins by outlining the fundamental working mechanisms of OECTs and their advantages in transducing biological signals. Key strategies to enhance bio\u2010tissue interfacing are discussed, including molecular functionalization, interface orientation control, and mechanical matching. The review also covers developments in OECT\u2010based systems for skin\u2010mounted and implantable applications, with a focus on maintaining stability and responsiveness under dynamic physiological conditions. 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