{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:42:48Z","timestamp":1783017768033,"version":"3.54.6"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003704","name":"Korea Research Institute of Chemical Technology","doi-asserted-by":"publisher","award":["KK2532\u201030"],"award-info":[{"award-number":["KK2532\u201030"]}],"id":[{"id":"10.13039\/501100003704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The COVID\u201019 pandemic has underscored the urgent need for deployable vaccine platforms capable of rapidly responding to emerging and re\u2010emerging variants of human coronaviruses. BP26, an outer membrane protein of the zoonotic bacterium\n                    <jats:italic>Brucella<\/jats:italic>\n                    , self\u2010assembles into a highly ordered, barrel\u2010like nanoparticle that can serve as a vaccine platform, demonstrating immunogenicity against the influenza virus and cancer when combined with specific antigens. Here, we expanded its versatility by incorporating the SpyTag\/SpyCatcher pair, enabling modular and site\u2010specific antigen conjugation via simple mixing. SpyCatcher was genetically fused to BP26, and SpyTag to the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) spike protein, generating RBD\u2010displaying BP26 nanoparticles (BP26\u2010RBD). Immunization of mice with BP26\u2010RBD elicited strong RBD\u2010specific and neutralizing antibody responses and conferred protection against lethal SARS\u2010CoV\u20102 challenge. This plug\u2010and\u2010play nanoparticle design supports antigen production in diverse expression systems, retains antigenic structure, and allows multivalent display, providing a cost\u2010effective and rapidly adaptable strategy for next\u2010generation vaccines targeting evolving viral threats.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513431","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:34:46Z","timestamp":1768390486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Modular Vaccine Platform Against SARS\u2010CoV\u20102 Based on Self\u2010Assembled Protein Nanoparticles"],"prefix":"10.1002","volume":"13","author":[{"given":"Seojung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biological Sciences KAIST Institute for the BioCentury Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"},{"name":"Center for Precision Bio\u2010Nanomedicine Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejin","family":"Jang","sequence":"additional","affiliation":[{"name":"Infectious Diseases Therapeutic Research Center Korea Research Institute of Chemical Technology (KRICT)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences KAIST Institute for the BioCentury Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"},{"name":"Center for Precision Bio\u2010Nanomedicine Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences KAIST Institute for the BioCentury Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Joon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences KAIST Institute for the BioCentury Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meehyein","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Diseases Therapeutic Research Center Korea Research Institute of Chemical Technology (KRICT)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-586X","authenticated-orcid":false,"given":"Sangyong","family":"Jon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences KAIST Institute for the BioCentury Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"},{"name":"Center for Precision Bio\u2010Nanomedicine Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13910"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.151"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00713-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0002-y"},{"key":"e_1_2_10_7_1","first-page":"8","article-title":"SARS\u2010CoV\u20102 Variants: Biology, Pathogenicity, Immunity and Control","volume":"4","author":"Uraki R.","year":"2025","journal-title":"Nature Reviews Microbiology"},{"key":"e_1_2_10_8_1","first-page":"162","article-title":"SARS\u2010CoV\u20102 Variant Biology: Immune Escape, Transmission and Fitness","volume":"21","author":"Carabelli A. 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