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This study developed 4\u2010mercaptobenzoic acid (MPBA)\u2010modified copper nanozymes (CuMPBA) to simultaneously combat bacterial infections and toxin\u2010triggered immune overactivation. CuMPBA binds bacterial surface polysaccharides via boronate ester bonds, neutralizing lipopolysaccharides (LPS) and lipoteichoic acid (LTA). It demonstrates dual enzymatic activity: peroxidase (POD)\u2010like and glutathione peroxidase (GPx)\u2010like activities for antimicrobial effects. Additionally, CuMPBA disrupts\n                    <jats:italic>Streptococcus pneumoniae (Sp)<\/jats:italic>\n                    metabolism by interfering with thiamine utilization, amino acid synthesis, DNA processes, and energy production. In burn\u2010ALI mice with secondary pneumonia, CuMPBA restored lung architecture, suppress TNF\u2010\u03b1\/IL\u20101\u03b2\/IL\u20106 levels, and modulated inflammatory pathways by activating Nrf2 while inhibiting NF\u2010\u03baB. These synergistic mechanisms (precise bactericidal action combined with toxin neutralization) establish CuMPBA as a promising dual\u2010target therapeutic strategy for complex burn\u2010associated ALI. The multifunctionality of nanozymes addresses both infection control and inflammation resolution, offering new potential for managing this severe pathological condition.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513536","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:35:47Z","timestamp":1758033347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phenylboronic Acid\u2010Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Haojie","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Burns The First Hospital Affiliated of Anhui Medical University Anhui Medical University  Hefei Anhui 230032 P. R. 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