{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:18:09Z","timestamp":1791433089706,"version":"4.3.3"},"reference-count":61,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12372316"],"award-info":[{"award-number":["12372316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303455"],"award-info":[{"award-number":["82303455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12202345"],"award-info":[{"award-number":["12202345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372895"],"award-info":[{"award-number":["82372895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12022206"],"award-info":[{"award-number":["12022206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M722534"],"award-info":[{"award-number":["2022M722534"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xtr052022008"],"award-info":[{"award-number":["xtr052022008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer metastasis is governed by physical cues at the cell\u2010matrix interface, with matrix stiffness, ligand density, and topography established as key determinants. Here, a fourth critical factor in cancer metastasis, the architecture of the cell\u2010surface glycocalyx is identified. Using MUC15 as a representative small glycoprotein, mathematical modeling and domain truncation experiments are combined to show that glycoprotein size distribution governs integrin adhesion states and metastatic outcomes. MUC15 localizes to focal adhesions and interact with integrins, while larger glycoproteins such as MUC1 are sterically excluded. These physical effects, rather than intracellular signaling, dictate adhesion state transitions: removing MUC15's ectodomain eliminated its anti\u2010metastatic effects, whereas removal of its cytoplasmic tail has no effect. In in vivo pancreatic cancer models, modulating MUC15 levels controlled metastasis as predicted by the mathematical model. These findings establish glycocalyx architecture as a mechanical regulator of cancer progression and suggest therapeutic strategies targeting glycoprotein size distribution.<\/jats:p>","DOI":"10.1002\/advs.202513552","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:39:07Z","timestamp":1760409547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis"],"prefix":"10.1002","volume":"12","author":[{"given":"Simei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Department of Anesthesiology &amp; Center for Brain Science The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Department of General Surgery Huashan Hospital Fudan University  12 Urumqi Road (M) Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Department of Geriatric Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Center for Brain Science The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaomin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Center for Brain Science The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian Jian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics  Nanjing 210016 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy M.","family":"Genin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Department of Mechanical Engineering &amp; Materials Science Washington University in St. Louis  St. Louis MO 63130 USA"},{"name":"NSF Science and Technology Center for Engineering Mechanobiology Washington University in St. Louis  St. Louis MO 63130 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710061 P. R. China"},{"name":"Pancreatic Disease Treatment Center of Xi'an Jiaotong University  Xi'an 710061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-1955","authenticated-orcid":false,"given":"Min","family":"Lin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41567-018-0186-9"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13535"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000604"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0183-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0134-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.062"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0234-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2761"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201910070"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061640"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.12.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14219-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp137"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13277"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0094-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.56098"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2518-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04652-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq1858"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30610-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0142-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0567-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.256503"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.024"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.044"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34424-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26454-x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.02.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01657-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.10.030"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem249"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.49641"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3336"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2016.09.026"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24662"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1568-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37101-y"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48910-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01428-1"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1658"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1173-8"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3904"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.120"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14101053"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12111677"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12465"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33854-0"},{"key":"e_1_2_9_52_1","first-page":"1372","volume":"7","author":"Suh H.","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3426"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801483"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2020.104041"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00270.2001"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006765117"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15321"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.024"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.03.005"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36521-0"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202513552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:08:54Z","timestamp":1786817334000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202513552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":61,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/advs.202513552"],"URL":"https:\/\/doi.org\/10.1002\/advs.202513552","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13552"}}