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In such systems, apparent catalytic performance arises from the intricate interplay between intrinsic microkinetics and inter\u2010particle transport phenomena. By explicitly resolving these coupled effects, DNMK provides mechanistic insight into how spatial particle arrangements and transport limitations govern overall reactor performance. A key innovation of this work is the integration of ML\u2010based surrogates to accelerate the microkinetic module, effectively bridging the large spatial and temporal scale mismatches between transport and catalytic reactions. This hybrid approach achieves up to a 750\u2010fold computational speed\u2010up while preserving full physical and chemical fidelity. The framework is demonstrated for sorption\u2010enhanced CO\n                    <jats:sub>2<\/jats:sub>\n                    hydrogenation to methanol, where DNMK identifies optimal catalyst\u2010sorbent configurations that maximize apparent activity and reactor\u2010scale performance. More broadly, DNMK establishes a high\u2010resolution, ML\u2010driven platform for digital catalytic experimentation, enabling predictive, in silico optimization of catalyst scaling, utilization, and process intensification. By allowing rapid, physically consistent evaluation of complex catalytic systems, DNMK reduces reliance on costly experimental trials and opens new pathways for data\u2010driven reactor and process design across diverse chemical engineering applications.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513649","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:56:38Z","timestamp":1764752198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Machine Learning\u2010Driven Pore\u2010Scale Network Model Coupling Reaction Kinetics and Interparticle Transport for Catalytic Process Design"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-8899","authenticated-orcid":false,"given":"Ming\u2010Liang","family":"Qu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Clean Energy Utilization Zhejiang University  Hangzhou 310027 China"},{"name":"Wenzhou Key Laboratory of Novel Optoelectronic and Nano Materials Institute of Wenzhou Zhejiang University  Wenzhou 325006 China"},{"name":"Department of Earth Science and Engineering Imperial College London  London SW7 2AZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Bin","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Sun Yat\u2010sen University  Zhuhai 519028 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Foroughi","sequence":"additional","affiliation":[{"name":"Department of Earth Science and Engineering Imperial College London  London SW7 2AZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Clean Energy Utilization Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyizhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology University of Cambridge  Cambridge CB3 0AS UK"},{"name":"Department of Chemical Engineering School of Engineering The University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Green Synenergy Co.  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