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In this study, a deoxyribonucleic acid (DNA)\u2010inspired, self\u2010healing hydrogel\u2010based delivery system\u2014ATG@Exo\n                    <jats:sup>Cur<\/jats:sup>\n                    \u2014is developed that synergistically promotes diabetic wound healing by modulating multiple pathological processes. This system features a double\u2010crosslinked, self\u2010healing hydrogel derived from natural polysaccharides, which leverages the principle of DNA base\u2010pairing to achieve controlled drug release and mechanical adaptability. Additionally, incorporating exosome\u2010loaded curcumin enhances its physicochemical stability and improves the targeted delivery efficiency. This study demonstrates that ATG@Exo\n                    <jats:sup>Cur<\/jats:sup>\n                    effectively scavenges reactive oxygen species, suppresses chronic inflammation, promotes angiogenesis, and modulates the immune microenvironment by inducing macrophage polarization toward a pro\u2010repair phenotype. By integrating biomaterial engineering with biological activity, this system overcomes the limitations of monotherapies and offers a novel, highly efficient, and safe approach for treating chronic diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513784","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T03:47:47Z","timestamp":1764301667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["DNA\u2010Inspired Multi\u2010Functional Double\u2010Cross\u2010Linking Self\u2010Healing Hydrogel Promotes the Healing of Diabetic Wounds"],"prefix":"10.1002","volume":"13","author":[{"given":"Pu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha 410011 China"},{"name":"Department of Plastic and Reconstructive Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha 410011 China"},{"name":"Department of Dermatology The Second Xiangya Hospital Central South University  Changsha Hunan 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naihsin","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyi","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering Central South University  Changsha Hunan 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Jian","sequence":"additional","affiliation":[{"name":"Engineering &amp; Design College Human Normal University  Changsha Hunan 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjie","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province Shulan International Medical College Institute of Translational Medicine Zhejiang Shuren University  Hangzhou Zhejiang 310015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-4238","authenticated-orcid":false,"given":"Bairong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha 410011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417801"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12605"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301064"},{"key":"e_1_2_8_4_1","first-page":"23","volume":"11","author":"Huelsboemer L.","year":"2024","journal-title":"Mil. 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