{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:10:36Z","timestamp":1789578636332,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371464"],"award-info":[{"award-number":["32371464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Spinal cord injury (SCI) triggers secondary pathological cascades, such as excitotoxicity, neuroinflammation, and glial scarring, creating a hostile injury microenvironment that exacerbates the death of spared neurons and inhibits axonal regeneration, thus impeding functional recovery. While aligned electrospun nanofibers (NFs) fabricated from decellularized extracellular matrix (dECM) can mimic topological and bioactive cues of native ECM to guide axonal regrowth, they fail to intervene in these secondary pathological cascades. To address this limitation, Mg\n                    <jats:sup>2+<\/jats:sup>\n                    and epigallocatechin gallate (EGCG) molecules are initially self\u2010assembled into nanoparticles (MPN NPs) via metal\u2013phenolic coordination, and then integrated with dECM by electrospinning to form an aligned fibrous scaffold, MPN@dECM NFs. These MPN NPs undergo pH\u2010responsive degradation in the acidic SCI microenvironment, releasing Mg\n                    <jats:sup>2+<\/jats:sup>\n                    to alleviate excitotoxicity by blocking Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx and EGCG to suppress neuroinflammation by reducing pro\u2010inflammatory mediators. In the mouse SCI model, MPN@dECM NFs consistently attenuate neuroinflammation and glial scarring, and ameliorate the regeneration\u2010inhibitory microenvironment, thereby not only protecting spared neurons from secondary degeneration but also enhancing dECM\u2010mediated axonal regeneration. Ultimately, surviving neurons and regenerating axons synergize to facilitate motor function restoration. Collectively, this scaffold design synergistically promotes neuroprotection and axonal regeneration, demonstrating enhanced repair efficacy for SCI as a promising therapeutic strategy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513825","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:29:28Z","timestamp":1761658168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroprotection and Axonal Regeneration via ECM\u2010Mimetic Nanofibers Incorporating Metal\u2013Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9174-6432","authenticated-orcid":false,"given":"Shu","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center of Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center of Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center of Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-7334","authenticated-orcid":false,"given":"Changsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center of Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-3684","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center of Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00287-9"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102598"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.18"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00199-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230078"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121786"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202510129"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120596"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09892"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119941"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303388"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121192"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1668"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2900"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.327325"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23926"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23344"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00573-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.369094"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01042"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00273J"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00150"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237265"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015862108"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911505"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002451"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2212069"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42826-023-00155-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.010"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.06.009"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302448"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11080772"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.057"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307068"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.40"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.024"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2010.02.006"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114877"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae049"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120559"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101329"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.04.015"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.214169"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0027-6"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-023-00278-z"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-007-8712-5"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2011.08.032"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020181"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/0897715041269641"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.01.001"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00278-7"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.1"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114575"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01084"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.48"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.28"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1719OC"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.901672"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50564-x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110628"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.91"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.635"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150150502613"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.537"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.005"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33184-1"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.730348"},{"key":"e_1_2_8_72_1","volume":"93","author":"Liu Z.","year":"2019","journal-title":"Neurology"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202513825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:59:45Z","timestamp":1774270785000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202513825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202513825"],"URL":"https:\/\/doi.org\/10.1002\/advs.202513825","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13825"}}