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Therefore, there is an urgent need to develop new non\u2010antibiotic approaches to eradicate drug\u2010resistant bacterial infections. Here, a bimetal\u2010phenolic framework (Que\u2010Fe\u2010CeMPF) is constructed by direct self\u2010assembly of coordinated Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and Ce\n                    <jats:sup>4+<\/jats:sup>\n                    ions with the polyphenol quercetin (Que). Que\u2010Fe\u2010CeMPF enhanced hydroxyl radical (\u00b7OH) generation, particularly in an acidic environment and presence of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2,<\/jats:sub>\n                    compared with single metal\u2010phenolic frameworks (Que\u2010FeMPF and Que\u2010CeMPF). \u00b7 OH damaged bacterial cell walls, resulting in intracellular protein loss and bacterial cell death. Additionally, Que\u2010Fe\u2010CeMPF effectively dispersed biofilms by degrading matrix eDNA, allowing easier \u00b7OH penetration, resulting in higher killing efficiency compared to Que\u2010FeMPF and Que\u2010CeMPF. Que\u2010Fe\u2010CeMPF stimulated macrophages to adopt an M2\u2010like phenotype, suppressing excessive immune activation and promoting tissue repair at the infection site. As a combined effect of bacterial killing, biofilm degradation, and immune\u2010modulation, the infectious pneumonia caused by\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    in mice is more effectively eradicated by Que\u2010Fe\u2010CeMPF than by free quercetin or the antibiotic ciprofloxacin. Moreover, Que\u2010Fe\u2010CeMPF is less prone to resistance development in pathogens compared to ciprofloxacin. Thus, Que\u2010Fe\u2010CeMPF is a promising non\u2010antibiotic antimicrobial agent with multimodal activity for controlling drug\u2010resistant bacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513863","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:46:08Z","timestamp":1758098768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bimetal\u2010Phenolic Framework to Combat Bacterial Infections via Synergistic Biofilm Dispersal, Bacterial Killing and Immune Modulation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yaran","family":"Wang","sequence":"first","affiliation":[{"name":"Consortium for Infection and Innovation (CII) Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325035 China"},{"name":"State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional 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