{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:04:01Z","timestamp":1789164241078,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG044546 (CC)"],"award-info":[{"award-number":["R01AG044546 (CC)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG003991(CC JCM)"],"award-info":[{"award-number":["P01AG003991(CC JCM)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG053303 (CC)"],"award-info":[{"award-number":["RF1AG053303 (CC)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG058501 (CC)"],"award-info":[{"award-number":["RF1AG058501 (CC)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG058922 (CC)"],"award-info":[{"award-number":["U01AG058922 (CC)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG074007 (YJS)"],"award-info":[{"award-number":["RF1AG074007 (YJS)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG10161 (DAB)"],"award-info":[{"award-number":["P30AG10161 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG72975 (DAB)"],"award-info":[{"award-number":["P30AG72975 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG15819 (DAB)"],"award-info":[{"award-number":["R01AG15819 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG17917 (DAB)"],"award-info":[{"award-number":["R01AG17917 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG46152 (DAB)"],"award-info":[{"award-number":["U01AG46152 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG61356 (DAB)"],"award-info":[{"award-number":["U01AG61356 (DAB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["4R33AG078799\u201002(FL)"],"award-info":[{"award-number":["4R33AG078799\u201002(FL)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21AG078799\u201001A1(FL)"],"award-info":[{"award-number":["1R21AG078799\u201001A1(FL)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG044546"],"award-info":[{"award-number":["R01AG044546"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Apolipoprotein E (APOE<\/jats:italic>\n                    ) \u03b54 is the strongest genetic risk factor for Alzheimer's disease (AD). However, it is known that other pathways independent of\n                    <jats:italic>APOE<\/jats:italic>\n                    also play a role in AD. Disentangling\n                    <jats:italic>APOE<\/jats:italic>\n                    \u2010dependent and independent effects is instrumental for understanding the biology of AD. We conducted an\n                    <jats:italic>APOE<\/jats:italic>\n                    \u2010stratified multi\u2010omic analysis in multiple large datasets to identify AD\u2010associated plasma proteins and metabolites. More than 64% of the identified proteins were not found in non\u2010\n                    <jats:italic>APOE<\/jats:italic>\n                    stratified studies, and 17% of the proteins showed\n                    <jats:italic>APOE<\/jats:italic>\n                    \u2010specific trends. Mitochondrial dysfunction was associated in AD independently of\n                    <jats:italic>APOE<\/jats:italic>\n                    and was accompanied by disruptions in glucose and lipid metabolism and cell death and increased in inflammatory signaling activation. Lipid upregulation was found in AD cases when compared with controls with the same\n                    <jats:italic>APOE<\/jats:italic>\n                    genotype, indicating that additional factors beyond\n                    <jats:italic>APOE<\/jats:italic>\n                    affect lipid regulation and AD risk. These findings may be informative in guiding the development of effective medications for AD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202513872","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:42:51Z","timestamp":1770309771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>APOE<\/i>\n                    \u2010stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Fuhai","family":"Li","sequence":"first","affiliation":[{"name":"Institute For Informatics (I2) Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"Department of Pediatrics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Western","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lowery","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Department of Neurology Knight Alzheimer's Disease Research Center Hope Center for Neurological Disorders .  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Robins","sequence":"additional","affiliation":[{"name":"Human Genetics &amp; Genomics Research Technologies GSK  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Eicher","sequence":"additional","affiliation":[{"name":"Human Genetics &amp; Genomics Research Technologies GSK  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"Center For Neuroimaging Indiana Alzheimer's Disease Research Center Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiWei","family":"Liu","sequence":"additional","affiliation":[{"name":"Center For Neuroimaging Indiana Alzheimer's Disease Research Center Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamina","family":"Park","sequence":"additional","affiliation":[{"name":"Center For Neuroimaging Indiana Alzheimer's Disease Research Center Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[{"name":"Center For Neuroimaging Indiana Alzheimer's Disease Research Center Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[{"name":"Center For Neuroimaging Indiana Alzheimer's Disease Research Center Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Moqri","sequence":"additional","affiliation":[{"name":"Division of Genetics Department of Medicine Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Mohs","sequence":"additional","affiliation":[{"name":"Global Alzheimer's Platform Foundation  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Farinas","sequence":"additional","affiliation":[{"name":"The Phil and Penny Knight Initiative for Brain Resilience Stanford University  Stanford California USA"},{"name":"Wu Tsai Neurosciences Institute Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Moran\u2010Losada","sequence":"additional","affiliation":[{"name":"The Phil and Penny Knight Initiative for Brain Resilience Stanford University  Stanford California USA"},{"name":"Wu Tsai Neurosciences Institute Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton Se\u2010Hwee","family":"Oh","sequence":"additional","affiliation":[{"name":"The Phil and Penny Knight Initiative for Brain Resilience Stanford University  Stanford California USA"},{"name":"Wu Tsai Neurosciences Institute Stanford University  Stanford California USA"},{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Wyss\u2010Coray","sequence":"additional","affiliation":[{"name":"The Phil and Penny Knight Initiative for Brain Resilience Stanford University  Stanford California USA"},{"name":"Wu Tsai Neurosciences Institute Stanford University  Stanford California USA"},{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-2899","authenticated-orcid":false,"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001024\u2010z"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100358\u20102"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3916"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24016"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010015\u20100016\u20109"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1306509"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000687\u20104"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau2291"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2301380"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2109455"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12385"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001972\u20108"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.041"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010024\u201001669\u20105"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100228\u20107"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62199"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007185\u20107"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz9360"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq5923"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12369"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.08.049"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.02.014"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.935279"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000999\u2010y"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054354"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13130"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100815\u20106"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12714"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adn3504"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000693\u20101"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.049"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000872\u20108"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.026"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20103617016\/v1"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004879"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20105167552\/v1"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001101"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00058"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001973\u20107"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000376\u20106"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010025\u201000803\u20106"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u201001104\u20107"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16344"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007516\u20108"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000756\u20104"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13111554"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21039"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14360"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.06.18.24309102"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.31.25339089"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.15.24304164"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.29.25339064"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597\u2010024\u201003485\u20109"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13722"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106373"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3978"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005694"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14313"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202513872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202513872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:09:25Z","timestamp":1776193765000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202513872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":65,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202513872"],"URL":"https:\/\/doi.org\/10.1002\/advs.202513872","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13872"}}