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Although exosome\u2010based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion\u2010associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose\u2010derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow\u2010derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. 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