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One such mutation, Uppsala APP (APPUpp), produces A\u03b2Upp42\n                    <jats:sub>\u039419\u201024<\/jats:sub>\n                    , whichis highly aggregation\u2010prone due to a six\u2010amino\u2010acid deletion in its central region.In both human APPUpp carriers and the recently developed tg\u2010UppSwe mouse model, A\u03b2 depositspredominantly consist of the human A\u03b2Upp mutant.However, whereas human carriers produce both wild\u2010type A\u03b2 (A\u03b2wt) and A\u03b2Upp, tg\u2010UppSwe mice express only A\u03b2Upp. To better mimic the human condition, weinvestigated the pathological interplay between A\u03b2wt and A\u03b2Upp using in vitroco\u2010aggregation assays and in vivo analyses in abitransgenic mouse model generated by crossing tg\u2010UppSwe with tg\u2010Swe mice. ELISA, immunohistochemistry, and MALDI mass spectrometry imaging revealed that earlydeposition of A\u03b2Upp42\n                    <jats:sub>\u039419\u201024<\/jats:sub>\n                    accelerates aggregation and deposition of A\u03b2wt species (A\u03b2wt38, A\u03b2wt40, A\u03b2wt42), likely through a seeding or catalytic mechanism. Notably, bitransgenic mice developed pronounced plaque\u2010associated gliosisan alteration absent in tg\u2010UppSwe animals. These findings suggest a synergistic interaction betweenA\u03b2Upp and A\u03b2wt that may influence onset, progression, and structural featuresof A\u03b2 plaques in APPUpp mutation carriers.\n                  <\/jats:p>","DOI":"10.1002\/advs.202514179","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:48:36Z","timestamp":1774986516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>Uppsala APP<\/i>\n                    Mutation Promotes Wild\u2010Type Amyloid\u2010\u03b2 Aggregation and Deposition In Vivo"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9542-802X","authenticated-orcid":false,"given":"Junyue","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry University of Gothenburg  Gothenburg 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