{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:08:47Z","timestamp":1791835727768,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A2099"],"award-info":[{"award-number":["U21A2099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403394"],"award-info":[{"award-number":["52403394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071391"],"award-info":[{"award-number":["82071391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["Y2023066"],"award-info":[{"award-number":["Y2023066"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intervertebral disc degeneration (IVDD) is a progressive degenerative disorder of the spine characterized by oxidative stress and cellular dysfunction. Current clinical treatments for IVDD include surgical procedures, such as discectomy and spinal fusion, as well as pharmacological therapies using analgesics and anti\u2010inflammatory agents. However, these strategies primarily offer symptomatic relief and do not address the underlying causes of IVDD. Targeting oxidative stress has emerged as a promising therapeutic approach, yet its effectiveness remains limited. To overcome this limitation, an antioxidant carbon dot of selenomethionine (Se\u2010Met\u2010CD) is developed for efficient IVDD therapy. Se\u2010Met\u2010CD effectively scavenges excess reactive oxygen species (ROS), alleviates oxidative stress, and restores intracellular redox homeostasis in nucleus pulposus cells. Se\u2010Met\u2010CD exhibits an antioxidant capacity 3.1 times that of its precursor, Se\u2010Met, when compared at the same concentration. In hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010treated nucleus pulposus cells, Se\u2010Met\u2010CD significantly reduces intracellular ROS levels to 17.7% of those in untreated control cells. In a puncture\u2010induced IVDD rat model, Se\u2010Met\u2010CD demonstrates remarkable therapeutic efficacy by significantly attenuating disc degeneration, reflected in lower Pfirrmann and histological scores. These results underscore the potential of Se\u2010Met\u2010CD to treat IVDD by scavenging ROS, restoring antioxidant balance, and modulating the local microenvironments.\n                  <\/jats:p>","DOI":"10.1002\/advs.202514217","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:08:48Z","timestamp":1758125328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-3971","authenticated-orcid":false,"given":"Qingzheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Center of Orthopedics The First Hospital of Jilin University  1 Xinmin Street Changchun 130061 P. R. 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