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While carbon quantum dots (CQDs) have emerged as pyroptosis\u2010triggering agents, their efficacy in NIR\u2010II light\u2010mediated therapy remains constrained by a low absorption coefficient and uncontrolled charge recombination. Herein, CQDs with high\u2010density self\u2010trapped excitons (STEs) exhibiting NIR\u2010II absorption and an exceptional photothermal conversion efficiency of 51.2% are engineered. By optimizing the migration dynamics of hot carriers, directional charge separation is achieved, which generates cytotoxic hydroxyl radicals and superoxide radicals. The synergistic photo\u2010thermoelectric catalysis triggers pyroptosis via reactive oxygen species\u2010caspase 1\u2010gasdermin D activation, eliciting robust systemic immunity that effectively eliminates the primary tumor and prevents tumor recurrence. This work establishes STE engineering as a universal design principle for advanced nanomaterials while pioneering a NIR\u2010II\u2010responsive pyroptosis platform that bridges localized ablation with systemic antitumor immunity, offering a paradigm shift for precision immuno\u2010oncology.<\/jats:p>","DOI":"10.1002\/advs.202514249","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:26:57Z","timestamp":1755926817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self\u2010Trapped Excitons in Carbon Quantum Dots with Large NIR\u2010II Photo\u2010Thermoelectric Catalysis Induce Pyroptosis for Cancer Therapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2071-7477","authenticated-orcid":false,"given":"Tesen","family":"Zhang","sequence":"first","affiliation":[{"name":"Interdisciplinary Institute of Medical Engineering Fuzhou University  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