{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:45:20Z","timestamp":1791477920208,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Air pollution (AP), intensified by industrialization and urbanization, is a key environmental factor linked to rheumatoid arthritis (RA). However, its molecular and immunological impact on RA remains unclear. This study integrates epidemiological data, bioinformatics, single\u2010cell transcriptomics, and animal models to investigate how AP contributes to the development of RA. Global epidemiological analysis shows rising RA prevalence in over 95% of countries. Mendelian randomization analysis indicated a positive correlation between PM\n                    <jats:sub>10<\/jats:sub>\n                    exposure and the risk of RA. Machine learning identifies Formin Binding Protein 1 (FNBP1) as a key air pollution\u2010related gene (APRG), with decreasing expression in RA patients and strong correlation with disease activity. PM\n                    <jats:sub>10<\/jats:sub>\n                    exposure may impair natural killer (NK) cell differentiation and cytotoxicity by suppressing FNBP1 expression, ultimately weakening immune surveillance and exacerbating inflammatory responses. Furthermore, by integrating single\u2010cell sequencing, animal models, and human\u2010derived cell experiments, we demonstrated that PM\n                    <jats:sub>10<\/jats:sub>\n                    exposure aggravates inflammation and joint damage in a collagen\u2010induced arthritis (CIA) model. Mechanistically, PM\n                    <jats:sub>10<\/jats:sub>\n                    likely impairs the cytotoxic function of CD56\n                    <jats:sup>dim<\/jats:sup>\n                    NK cells through the modulation of FNBP1. Taken together, our research results have unveiled a completely novel mechanistic hypothesis regarding the onset and development of RA, the \u201cPM\n                    <jats:sub>10<\/jats:sub>\n                    \u2010FNBP1\u2010NK cells\u201d axis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202514260","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:24:57Z","timestamp":1771586697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["PM\n                    <sub>10<\/sub>\n                    Impairs CD56\n                    <sup>dim<\/sup>\n                    NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi\u2010Omics"],"prefix":"10.1002","volume":"13","author":[{"given":"Runhan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongging P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongging P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Public Health Chongqing Medical University  Chongging P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongging P. 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