{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:59:12Z","timestamp":1790935152662,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22001091"],"award-info":[{"award-number":["22001091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lipoproteins, critical transporters of cholesterol and triglycerides, are essential to cardiovascular health and pathology. However, imaging probes that can specifically target endogenous lipoproteins in situ are lacking. This study introduces an innovative lipoprotein\u2010seeking near\u2010infrared\u2010II (NIR\u2010II) dye for in vivo imaging of lipid dysregulation diseases independent of immune interactions. This dye demonstrates high affinity and specificity for lipoproteins, enabling in situ selective lipoprotein\u2010seeking within the body, unaffected by other proteins. The lipoprotein\u2010seeking dynamics can be precisely modulated through rationally tuning hydrophilic moieties of dye structure. The lipoprotein\u2010seeking dye enables the real\u2010time high\u2010contrast detecting subtle biological changes associated with lipid metabolism disorders, successfully delineating the presence of fatty deposits in hepatic tissues and identifying the early formation of atherosclerotic plaques in cardiovascular systems. Notably, our dye can selectively image low density lipoprotein (LDL) without highlighting high density lipoprotein (HDL) through appropriate irradiation. The NIR\u2010II dye's ability to target lipoproteins and provide clear imaging could revolutionize the management of lipoprotein\u2010related conditions, facilitating earlier interventions and more personalized treatment strategies.<\/jats:p>","DOI":"10.1002\/advs.202514290","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:55:48Z","timestamp":1769514948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In Situ Lipoprotein\u2010seeking Dye for in Vivo Real\u2010Time Imaging of Lipid Dysregulation Diseases"],"prefix":"10.1002","volume":"13","author":[{"given":"Yijing","family":"Du","sequence":"first","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials Center For Supramolecular Chemical Biology College of Chemistry Jilin University  Changchun P.R. China"},{"name":"Changbaishan Laboratory Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zetao","family":"Dang","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials Center For Supramolecular Chemical Biology College of Chemistry Jilin University  Changchun P.R. China"},{"name":"Changbaishan Laboratory Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Stroke Center Department of Neurology First Hospital of Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xu","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials Center For Supramolecular Chemical Biology College of Chemistry Jilin University  Changchun P.R. China"},{"name":"Key Laboratory of Chemical Biology of Hebei Province College of Chemistry and Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University  Baoding P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"},{"name":"Changbaishan Laboratory Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-6121","authenticated-orcid":false,"given":"Shoujun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry First Hospital of Jilin University  Changchun P.R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials Center For Supramolecular Chemical Biology College of Chemistry Jilin University  Changchun P.R. China"},{"name":"Changbaishan Laboratory Jilin University  Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101238"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010023\u201000741\u2010w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010016\u20101002\u20106"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059749"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2023.11.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010021\u201000584\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021204288"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566\u2010024\u201001391\u20105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900321"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010024\u201001275\u20107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh7828"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh1037"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010019\u20100494\u20100"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001422\u20102"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u201000554\u20105"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010022\u201001394\u20106"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010023\u201001003\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010024\u201000301\u2010x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318800"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70040"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300439"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119963"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.03.019"},{"key":"e_1_2_9_27_1","article-title":"Tumor\u2010Activatable Nanoparticles Target Low\u2010Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy","volume":"9","author":"Jiang X.","year":"2022","journal-title":"Advance Science"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15678"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01271E"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc900404y"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010018\u20103626\u20104"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169\u2010409X(01)00109\u20100"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.159025"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.08.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10092473"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc300561e"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja069336k"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200017e"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00667"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121076"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119282"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.05.010"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw0672"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.03.019"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015323\u20108"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311515"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.135910"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047063\u20104"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306773"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02396C"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14010012"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000933"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.38.070169.000553"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0970615"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx226"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.1995.1039"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109991(83)90014\u20101"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1887\/0852743920"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101447"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202514290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:19:32Z","timestamp":1775125172000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202514290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":59,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202514290"],"URL":"https:\/\/doi.org\/10.1002\/advs.202514290","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14290"}}