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The concave geometry enables passive self\u2010alignment of millimeter\u2010scale COs within a multichannel electrode array, allowing simultaneous extracellular field potential (EFP) recording and video\u2010based motion analysis. Using COs derived from human induced pluripotent stem cells of healthy donors and a DMD patient, we resolved region\u2010specific EFP waveforms, which were validated by calcium imaging. DMD COs exhibited severe arrhythmic firing and aberrant waveform morphologies, in contrast to the stable, isochronal rhythms of healthy controls. Single\u2010cell transcriptomic analysis revealed a pathological DMD signature marked by excessive extracellular matrix accumulation and disorganized cardiac architecture, contributing to conduction heterogeneity. Pharmacological challenge with the hERG blocker E\u20104031 prolonged field potential duration in normal COs but triggered disorganized arrhythmogenic storms in DMD COs. By overcoming the limitations of rigid interfaces and ensuring structural preservation with stable impedance coupling, the presented platform provides a robust biointerface for disease phenotyping, drug screening, and mechanistic interrogation of 3D cardiac tissues.<\/jats:p>","DOI":"10.1002\/advs.202514365","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:48:46Z","timestamp":1774871326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conformable Microelectrode Arrays Integrated with a Scoop\u2010Shaped Slide\u2010Well for Dynamic Electrophysiological Profiling of Patient\u2010Derived Cardiac Organoids"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-1385","authenticated-orcid":false,"given":"Ye Seul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology Department of Convergence Stem Cell Research 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