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However, its systemic immunomodulatory effects remain poorly understood. Here, we discovered that irradiated tumor cell\u2010derived microparticles (RT\u2010MPs) are released into the circulation and subsequently taken up by neutrophils in the spleen. The mitochondrial DNA contained within RT\u2010MPs promotes the hyperactivation of neutrophils, leading to the secretion of interleukin\u20101beta (IL\u20101\u03b2) via the STING\/NLRP3\/GSDMD axis. IL\u20101\u03b2, in turn, enhances the antigen\u2010presenting capacity of dendritic cells (DCs), which facilitates the formation of cytotoxic T lymphocytes (CTLs) in the spleen. These CTLs then contribute to the destruction of distant, non\u2010irradiated tumors. Our findings provide valuable insights into the mechanisms by which radiotherapy can directly modulate systemic anti\u2010tumor immunity, highlighting the potential for leveraging these effects to improve the efficacy of cancer treatment.<\/jats:p>","DOI":"10.1002\/advs.202514390","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:50:46Z","timestamp":1767595846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Irradiated Tumor Cell\u2010Derived Microparticles Activate Systemic Anti\u2010Tumor Immunity via the STING\/NLRP3\/GSDMD Axis in Neutrophils"],"prefix":"10.1002","volume":"13","author":[{"given":"Yan","family":"Hu","sequence":"first","affiliation":[{"name":"Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of 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