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However, MC targeting using existing gene delivery platforms faces many barriers to clinical use, such as production scalability and off\u2010target delivery to the liver and non\u2010MCs. Here, a novel peptide dendrimer\u2010lipid (PDL) nanocarrier for systemic administration, which overcomes many of these barriers, is characterized. This MC targeting nanocarrier (MCTN) is self\u2010assembling, de\u2010targets the liver, and selectively targets the spleen and MCs within the tumor microenvironment (TME). MCTN is validated as a cancer vaccine platform utilizing full\u2010length antigens, generating robust immune responses with broad HLA\u2010haplotype coverage. Finally, using a payload encoding constitutively active interferon regulatory factor 5 (IRF5), MCTN is found to suppress solid tumor growth and modulate the TME by improving CD8+ T\u2010cell infiltration while depleting immunosuppressive cells.<\/jats:p>","DOI":"10.1002\/advs.202514417","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T19:47:36Z","timestamp":1758311256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Precision Targeting of Myeloid Cells via Peptide Dendrimer\u2010Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-6766","authenticated-orcid":false,"given":"Lawrence James","family":"Billing","sequence":"first","affiliation":[{"name":"Nuntius Therapeutics Limited  London W10 5JJ 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