{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:46:35Z","timestamp":1781534795662,"version":"3.54.5"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2306300"],"award-info":[{"award-number":["2023YFC2306300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32225019"],"award-info":[{"award-number":["32225019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92357304"],"award-info":[{"award-number":["92357304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32394003"],"award-info":[{"award-number":["32394003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260260"],"award-info":[{"award-number":["82260260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011620","name":"Center for Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mast cells are tissue\u2010resident immune sentinels. However, their spatial localization and potential role in the antiviral response within the meninges\u2014the protective barrier surrounding the central nervous system\u2014remain unclear. Here, the distribution pattern along meningeal vasculature is maped and identified a post\u2010weaning maturation process. Single\u2010cell RNA sequencing reveals that mast cells mount a robust immune response against LCMV infection. Ablation of mast cells results in reduced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and impairs viral clearance. Mechanistic dissection identifies a critical role for the IL\u201033 receptor on mast cells, which responds to IL\u201033 derived from stromal cells, in mediating antiviral immunity. Further analysis shows that mast cells synergistically upregulate cytokines and chemokines in response to IL\u201033 and ATP released by virus\u2010infected stromal cells. Collectively, these findings reveal a critical role for mast cells in enhancing meningeal antiviral immunity and highlight potential strategies for brain protection during infection.\n                  <\/jats:p>","DOI":"10.1002\/advs.202514842","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:08:35Z","timestamp":1762423715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stromal Cell\u2010Mast Cell Communication Orchestrates Anti\u2010Viral Immunity in the Meninges"],"prefix":"10.1002","volume":"13","author":[{"given":"Qingqing","family":"Li","sequence":"first","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Ni","sequence":"additional","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital of Zunyi Medical University  Zunyi 563000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital of Zunyi Medical University  Zunyi 563000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-3318","authenticated-orcid":false,"given":"Wenwen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute for Immunology and School of Basic Medical Sciences Beijing Key Laboratory of Immunological Research of Allergy (LIRA) Tsinghua University  Beijing 100084 China"},{"name":"SXMU\u2010Tsinghua Collaborative Innovation Center for Frontier Medicine Shanxi Medical University  Taiyuan 030001 China"},{"name":"Tsinghua\u2010Peking Center for Life Sciences  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.932090"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230570"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00622-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00795.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000126"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-102319-103410"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf9277"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.09.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0213-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3423"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat7554"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0393-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2886-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0344-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.04.012"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adg6155"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069231181358"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.874193"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.09.039"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00126"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.06.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.045"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.046"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3690"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122538"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.045"},{"key":"e_1_2_9_33_1","first-page":"620","volume":"6","author":"Krystel\u2010Whittemore M.","year":"2015","journal-title":"Front. Immunol."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.10.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216580"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.06.003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0493-z"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.688347"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486217"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.06.015"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/381077a0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.040"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14633"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12263584"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7174"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.08.007"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00475"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.007"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101320-124243"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01043-8"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.014"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07591"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.127"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112281119"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm9903"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0697-2"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182031"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0301-x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat1604"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.798660"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.022"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12197-3"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.09.006"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113141"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.03.009"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.718499"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)02334-X"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.049"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13386"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104470"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint16060127"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685865"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042249"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009066"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4235"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.2741\/3021"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1418897"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155891"},{"key":"e_1_2_9_81_1","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc15a01s8","volume":"8","author":"Welsh R. M.","year":"2008","journal-title":"Curr. Protoc. Microbiol."},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1293-3"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05753-x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00046-19"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.12.012"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01051-9"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn025"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_96_1","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0738s91","volume":"91","author":"Kuehn H. S.","year":"2010","journal-title":"Curr. Protoc. Immunol."},{"key":"e_1_2_9_97_1","volume":"113","author":"Windt G. J. W.","year":"2016","journal-title":"Curr. Protoc. Immunol."},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2688"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202514842","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T15:38:46Z","timestamp":1769528326000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202514842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202514842"],"URL":"https:\/\/doi.org\/10.1002\/advs.202514842","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14842"}}