{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:51:49Z","timestamp":1791841909979,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171118"],"award-info":[{"award-number":["82171118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403801"],"award-info":[{"award-number":["82403801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ41027"],"award-info":[{"award-number":["2021JJ41027"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6631"],"award-info":[{"award-number":["2024JJ6631"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by extensive immune cell infiltration. However, the function and significance of B cells in NPC have been overlooked. Exploring B cells and their interactions with other immune cells will provide deeper insights into the immune microenvironment of NPC and theories of immunotherapy.We utilized single\u2010cell sequencing data to identify characteristic B cell subtypes of NPC. Subsequently, the presence of the CD20\n +<\/jats:sup>\n FCRL4\n +<\/jats:sup>\n B cell subpopulation was validated in NPC samples using immunohistochemistry and flow cytometry. The interaction between this B cell subpopulation and CD8\n +<\/jats:sup>\n T cells was investigated by establishing an in vitro and in vivo co\u2010culture system.Our analysis revealed a subset of CD20\n +<\/jats:sup>\n FCRL4\n +<\/jats:sup>\n B cells that may interact with CD8\n +<\/jats:sup>\n T cells through the MHC\u2010I pathway. Furthermore, we observed a co\u2010localized distribution of CD20\n +<\/jats:sup>\n FCRL4\n +<\/jats:sup>\n B cells and CD8\n +<\/jats:sup>\n T cells in NPC. Additionally, in vitro experiments demonstrated that IFN\u03b3 played a pivotal role in enhancing the delivery of MHC class I\u2010restricted epitope peptides by B cells, potentially due to the upregulation of WDFY4. B cells pre\u2010stimulated with HK\u20101 lysate and IFN\u03b3, when co\u2010cultured with T cells, can induce the proliferation of CD8\n +<\/jats:sup>\n T cells and the formation of immunological memory. Ultimately, this process mediates the cytotoxicity of CD8\n +<\/jats:sup>\n T cells against tumor cells both in vitro and in vivo. Notably, we found a positive correlation between the infiltration level of CD20\n +<\/jats:sup>\n FCRL4\n +<\/jats:sup>\n B cells and the expression of PD\u20101, as well as the response to anti\u2010PD\u20101 therapy or gemcitabine plus cisplatin combined with anti\u2010PD\u20101 therapy in NPC.Overall, our study elucidates the potential anti\u2010tumor mechanisms of CD20\n +<\/jats:sup>\n FCRL4\n +<\/jats:sup>\n B cells and provides insights into their role in immunotherapy for NPC.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/advs.202514982","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:26:34Z","timestamp":1767875194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CD20\n +<\/sup>\n FCRL4\n +<\/sup>\n B Cells Activate CD8\n +<\/sup>\n T Cells via MHC\u2010I Restriction in Nasopharyngeal Carcinoma Anti\u2010Tumor Immunity"],"prefix":"10.1002","volume":"13","author":[{"given":"Benjian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"},{"name":"Department Of Head and Neck Surgery Guangxi Medical University Cancer Hospital Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"You","sequence":"additional","affiliation":[{"name":"Institute of Otolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Nantong Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Third Hospital of Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Guizhou Medical University Guiyang Guizhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihai","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-8923","authenticated-orcid":false,"given":"Weihong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital of Central South University Changsha P. R. China"},{"name":"Anatomy Laboratory of Division of Nose and Cranial Base Clinical Anatomy Center of Xiangya Hospital Central South University Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21795-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00524-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3914"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.0388"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2016.04.02"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359221096214"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30495-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0096-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.11.043"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1015283"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31252"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.2.341"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188632"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.044"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.10.009"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109591"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03144-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1914-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18968"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.01.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02369-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-3714"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-20-0949"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002101"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.038"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2762"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3319"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.678127"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0057-z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000293"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179793"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8509805"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60811-y"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-0545"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2219956120"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800399"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5030"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2023.09.002"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15072133"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.935749"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.857137"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0374-x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21043-4"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01164-9"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2859"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0249"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4772-0"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2021.100293"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv639"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202514982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202514982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:59:09Z","timestamp":1772963949000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202514982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":56,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/advs.202514982"],"URL":"https:\/\/doi.org\/10.1002\/advs.202514982","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14982"}}