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Although intravesical therapies, such as quercetin and hyaluronic acid (HA), show potential, their efficacy is limited by rapid urinary clearance. Hydrogels offer potential as sustained\u2010release drug carriers and protective barriers, yet designing adhesive hydrogels with optimal wet tissue adhesion, controlled degradation, and regulation of anti\u2010inflammation remains difficult. Here it is aimed to develop a supramolecular gelatin\u2010based hydrogel adhesive (HADA\/gelatin\/Ac\u2010\u03b2\u2010CD\/quercetin, HGCQ) that combines acrylated \u03b2\u2010cyclodextrin as a dynamic crosslinker and hydrophobic drug carrier with dopamine\u2010functionalized HA for enhanced tissue adhesion and antioxidant functionality. The HGCQ hydrogel exhibits controlled degradation in artificial urine with sustained quercetin release over 48\u00a0h, exceptional burst pressure tolerance of up to 18.8\u00a0kPa on the bladder, and rapid hemostatic capability with a clotting time of 15 s. Crucially, HGCQ demonstrates comprehensive therapeutic effects including pro\u2010angiogenic potential, and broad\u2010spectrum antimicrobial efficacy, potent reactive oxygen species scavenging with a clearance of 600 \u00b5\n                    <jats:sc>m<\/jats:sc>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , and anti\u2010inflammatory activity mediated by nuculear factor kappa\u2010B (NF\u2010\u03baB)\/interleukin (IL)\u201017 pathways. In hemorrhagic cystitis models, HGCQ restores urothelial barrier function, promotes collagen III deposition, and reduces inflammation, making a significant advancement in managing this condition with potential applications in other wound healing scenarios.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515003","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T07:30:38Z","timestamp":1762587038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Under\u2010Urine\u2010Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9536-3409","authenticated-orcid":false,"given":"Xu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Urology Translational Research Laboratory for Urology Ningbo Clinical Research Center for Urological Disease The First Affiliated Hospital of Ningbo University Zhejiang Engineering Research Center of Innovative Technologies and Diagnostic and Therapeutic Equipment for Urinary System Diseases  Ningbo Zhejiang 315010 China"},{"name":"Research Institute of Smart Medicine and Biological Engineering Health Science Center Ningbo University  Ningbo Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Institute of Smart Medicine and Biological Engineering Health Science Center Ningbo University  Ningbo Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Translational Research Laboratory for Urology Ningbo Clinical Research Center for Urological Disease The First Affiliated Hospital of Ningbo University Zhejiang Engineering Research Center of Innovative Technologies and Diagnostic and Therapeutic Equipment for Urinary System Diseases  Ningbo Zhejiang 315010 China"},{"name":"Research Institute of Smart Medicine and Biological Engineering Health Science Center Ningbo University  Ningbo Zhejiang 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Translational Research Laboratory for Urology Ningbo Clinical Research Center for Urological Disease The First Affiliated Hospital of Ningbo University Zhejiang Engineering Research Center of Innovative Technologies and Diagnostic and Therapeutic Equipment for Urinary System Diseases  Ningbo Zhejiang 315010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology Translational Research Laboratory for Urology Ningbo Clinical Research 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