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However, previous reports mainly focused on thermodynamic modulation through molecular engineering to block the Type\u2010II energy transfer pathway. Herein, we present a facile strategy to realize the conversion of Type II to Type I PDT by integrating liposomal confinement and electron\/hydrogen transfer pathway. A multifunctional nanoplatform,\n                    <jats:bold>RhM\u2010R837@Lip<\/jats:bold>\n                    was developed, which facilitates an efficient shift from Type II to Type I for hemicyanine\u2010based photosensitizer (PS) by suppressing singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation while promoting superoxide anion (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ) and hydroxyl radical (\u2022OH). Lipids serve as electron donors, facilitating electron transfer to form PS radical anions. Additionally, liposomal nanoconfinement acts as a photothermal nanoreactor, achieving a photothermal conversion efficiency as high as 56.1%. Co\u2010encapsulation of immunoadjuvant R837 stimulates systemic immune responses, synergistically enhancing tumor eradication. This radical\u2010switching behavior, driven by liposomal nanoconfinement and the donor\u2013\u03c0\u2013acceptor (D\u2010\u03c0\u2010A) structural configuration, modulates electron transfer pathways to favor Type\u2010I photoreactions. The\n                    <jats:bold>RhM\u2010R837@Lip<\/jats:bold>\n                    nanoplatform provides a versatile, integrated strategy to overcome hypoxic tumor microenvironments, improving PDT and photocatalytic performance, and effectively inhibits tumor metastasis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515013","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T13:22:38Z","timestamp":1771161758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal\u2010Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Minglu","family":"Zhang","sequence":"first","affiliation":[{"name":"Qingdao Central Hospital NHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery Industry\u2010Academia\u2010Research Collaborative and Innovation 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