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Herein, a spatiotemporally controllable smart nanodevice based on upconversion nanoparticles (UCNPs) that can be activated by dual near \u2010 infrared (NIR) light for tumor immunotherapy, namely PURH, is developed. PURH is constructed by a five\u2010layer UCNPs surface coated with mesoporous silica, which encapsulates the photosensitizer rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN)\u00a0is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA) to achieve tumor targeting. PURH allows for dual NIR light activation, where 980\u00a0nm NIR light irradiation activates photodynamic therapy (PDT), inducing apoptosis and immunogenic cell death (ICD), while 808\u00a0nm NIR light irradiation triggers the release of CpG for tumor immunotherapy. The study offers a powerful tool and strategy for spatiotemporal controlled tumor immunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202515052","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:35:31Z","timestamp":1763753731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Spatiotemporally Controlled Tumor Photodynamic\/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem"],"prefix":"10.1002","volume":"13","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[{"name":"Translational Medicine Center Beijing Chest Hospital Capital Medical University &amp; Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing 101149 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Translational Medicine Center Beijing Chest Hospital Capital Medical University 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