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The significant temporal disconnect and lack of coordination between thrombolysis (\u226515% hemorrhage risk from short half\u2010life thrombolytics) and IS treatment results in limited clinical efficacy. Innovative strategies are required to: 1) resolve stereochemical conflicts in single\u2010molecule multifunctional materials; 2) enable spatiotemporal functions for effective diagnosis and treatment; 3) establish unambiguous structure\u2010property relationships. Herein, 4IrMn nanoparticles (NPs), with a dual transition metal core exhibit an endogenous peroxynitrite (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) response, which triggers near\u2010infrared chemiluminescence (NIR\u2010CL) signals for the precise location of lesion sites. Under laser irradiation, 4IrMn NPs initiate synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) in mouse thrombus models to achieve effective thrombolysis (the relative volume of clots decreased by \u224860%) with no observed hemorrhagic complications or recurrent embolism. After thrombolysis, 4IrMn NPs effectively scavenge excess cytotoxic reactive oxygen\/nitrogen species (RONS) and suppresses pro\u2010inflammatory cytokines such as tumor necrosis factor\u2010alpha\/interleukin\u20106 (TNF\u2010\u03b1 and IL\u20106). Ultimately, 4IrMn NPs enhance neuronal survival in the ischemic penumbra and reduce the extent of cerebral tissue death. This single\u2010molecule\u2010based multifunctional nanosystem integrates diagnostic\u2010therapeutic\u2010prognosis features, realizing a significant advance in addressing the constraints of current thrombosis and IS treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515079","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T03:50:49Z","timestamp":1759722649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Metalloporphyrin Nanosystem Enables Non\u2010Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke"],"prefix":"10.1002","volume":"12","author":[{"given":"Ziwei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Department of Chemistry Northeast Normal University  5268 Renmin Street Changchun Jilin Province 130024 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