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However, how adipose\u2010mediated signals intersect with local testicular immunity remains unclear. In this study, single\u2010cell RNA sequencing (scRNA\u2010seq) of human and mouse testes identified a conserved CD206\n                    <jats:sup>Lo<\/jats:sup>\n                    MHCII\n                    <jats:sup>Hi<\/jats:sup>\n                    macrophage subset, which undergoes CMKLR1\u2010mediated metabolic reprogramming toward glycolysis and pro\u2010inflammatory state during middle age. This immunometabolic shift is further found to impair spermatogenesis. CMKLR1 is identified as a viable target in vivo for restoring immunometabolic balance in aging testes. 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