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Here, 1.15 million records of six semen quality traits from 14\u00a0210 boars in four distinct breeds were collected. These traits have low to moderate heritability (0.12\u20130.26), and are genetically correlated with growth traits like average daily gain. Genome\u2010wide association study (GWAS) and multi\u2010breed meta\u2010analysis detected 234 loci associated with semen quality. Systematic integration of the Pig Genotype\u2010Tissue Expression resource with these GWAS loci allowed the prioritization of 93 causal variants targeting 134 genes. For instance, the expression quantitative trait loci (eQTL) of\n                    <jats:italic>NAXE<\/jats:italic>\n                    in multiple tissues were colocalized with a GWAS loci of the number of sperms, while eQTL of\n                    <jats:italic>LEFTY2<\/jats:italic>\n                    in the testis was exclusively colocalized with in a GWAS loci of semen volume. Through examining GWAS of semen quality traits in cattle and human complex traits, the ortholog genes (e.g.,\n                    <jats:italic>AURKAIP1<\/jats:italic>\n                    and\n                    <jats:italic>ADRA2A<\/jats:italic>\n                    ) significant in pigs also regulated bovine semen quality, and were significantly enriched for heritability of human birth weight and height. This study provides novel insights into semen quality traits in mammals, which will provide candidate genes for pig selective breeding and potential targets for human male infertility research.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515203","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T13:39:01Z","timestamp":1767879541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Meta\u2010GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-9748","authenticated-orcid":false,"given":"Qing","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Lab of Agro\u2010Animal Genomics and Molecular Breeding College 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