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In this study, a therapeutic platform is constructed on a magnesium (Mg) surface utilizing self\u2010healing thiolated hyaluronic acid (HA\u2010SH) and cell membrane\u2010derived vesicle (CMV) drug system, which improves structural stability, enables spatiotemporal drug release, and facilitates immune\u2010hormone combination therapy for prostate cancer. CMV with phospholipid bilayers promotes HA\u2010SH disulfide bond interactions through weak hydrophobic interactions, mitigating corrosion and ensuring structural integrity. Additionally, HA\u2010SH exhibits glutathione (GSH)\u2010responsive drug release within the tumor microenvironment. CMV facilitates pH\u2010sensitive drug delivery and enables efficient cytoplasmic entry via membrane fusion mechanisms, ensuring precise spatiotemporal control. Through drug library screening, ginsenoside Rb1 is identified as a key therapeutic agent, competitively inhibiting androgen receptor signaling. Coupled with hydrogen release from Mg, it induces immunogenic cell death and promotes the formation of tertiary lymphoid structures (TLS) via inhibiting the PI3K\u2010AKT pathway, achieving synergistic androgen deprivation therapy and immune activation. This implantable drug delivery system effectively tackles mechanical stability, local drug delivery, and systemic immune activation concerns, demonstrating substantial translational promise for various malignancies to improve treatment effectiveness and reduce structural failure risks.<\/jats:p>","DOI":"10.1002\/advs.202515235","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:30:11Z","timestamp":1766485811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnesium Structure\u2010Function Integration Platform for Spatiotemporal Multi\u2010Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Rui","family":"Zan","sequence":"first","affiliation":[{"name":"Department of Biliary Surgery Zhongshan Hospital &amp; College of Biomedical Engineering &amp; Yiwu Research Institute Fudan University Shanghai 200032 P. 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