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Here, this work reports the design, synthesis, and comprehensive characterization of a rationally designed silver(III) corrole complex,\n                    <jats:bold>(Mor\u2010Cor)Ag(III)<\/jats:bold>\n                    featuring a morpholino substituent at the periphery of the macrocycle, engineered to overcome these challenges through: (1) a morpholino moiety enabling BBB penetration (validated by mass spectrometry and fluorescence imaging), and (2) a redox\u2010active Ag(III) center that scavenges A\u03b242\u2010induced reactive oxygen species (ROS). Detailed structural, spectroscopic, and density functional theory (DFT) analyses are performed to elucidate the electronic features of the complex. Further through multimodal biological validation in in vitro and in vivo transgenic AD models,\n                    <jats:bold>(Mor\u2010Cor)Ag(III)<\/jats:bold>\n                    is shown to disrupt A\u03b242 aggregation and decrease ROS levels leading to decrease in dystrophic neurites, neuronal hyperactivity and neuronal death.\n                    <jats:bold>(Mor\u2010Cor)Ag(III)<\/jats:bold>\n                    significantly outperformed its unsubstituted analog,\n                    <jats:bold>(Cor)Ag(III)<\/jats:bold>\n                    in its ability to provide neuroprotection. This work establishes morpholine\u2010appended metallocorroles as a new class of neuroprotective drugs to address unmet therapeutic needs in AD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515462","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:51:28Z","timestamp":1767873088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Blood\u2010Brain Barrier\u2010Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting A\u03b242\u2010Induced Oxidative Stress"],"prefix":"10.1002","volume":"13","author":[{"given":"Arup","family":"Tarai","sequence":"first","affiliation":[{"name":"School of Chemical Sciences National Institute of Science Education and Research (NISER)  Bhubaneswar 752050 India"},{"name":"An OCC of HBNI Training School Complex  Anushakti Nagar Mumbai 400 094 India"},{"name":"Department of Chemistry Mahila Mahavidyalaya (MMV) 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