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Furthermore, the structural diversity of endotoxins across different bacterial species poses a major limitation on the clearance efficiency of structure\u2010specific anti\u2010endotoxin antibodies. In this study, a peptide\u2010based material with membrane\u2010disrupting functionality is developed. The topological configuration of the peptide is immobilized through Ni\n                    <jats:sup>2+<\/jats:sup>\n                    coordination, and the thrust force generated by a redox reaction is harnessed to facilitate deep tissue penetration and enhance resistance to oxidative degradation. Notably, it is discovered that the immobilized peptide\u2010based nanomotor storage system, coated with red blood cell membranes, can effectively mitigate colitis\u2010induced damage by concentrating and sequestering endotoxins while distributing the bacterial burden. This approach operates independently of molecular structure\u2010specific binding. Following endotoxin capture, the nanomotor storage system utilizes electrostatic interactions from immobilized peptide to adsorb endotoxins, thereby preventing excessive release of pro\u2010inflammatory cytokines during prolonged infection, ultimately enabling effective management of bacterial colitis. The top\u2010down fabrication of endotoxin storage materials presents a broadly applicable strategy against bacterial infections. The peptides immobilized via metal coordination offer an efficient pathway for bacterial and endotoxin capture, enabling the development of comprehensive storage systems.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515620","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T21:15:17Z","timestamp":1764450917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuxin","family":"Fang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Nutrition and Immunity College of Animal Science and Technology Northeast Agricultural University  Harbin 150030 P. R. 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