{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:31:38Z","timestamp":1787671898288,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474338"],"award-info":[{"award-number":["82474338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274364"],"award-info":[{"award-number":["82274364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774011"],"award-info":[{"award-number":["81774011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230018"],"award-info":[{"award-number":["82230018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreatic adenocarcinoma (PAAD), characterized by an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, exhibits a dismal prognosis further exacerbated by obesity. This study demonstrates the potent immunomodulatory and antitumor effects of coixenolide, a bioactive fatty acid ester from Coix lacryma\u2010jobi L., particularly in obesity\u2010associated PAAD. Utilizing high\u2010fat diet (HFD)\u2010fed mouse models, we found that coixenolide significantly inhibited tumor growth in HFD mice compared to control diet (CD) mice, correlating with enhanced intra\u2010tumoral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and cytotoxicity, reduced regulatory T cells (Tregs), and increased tumor cell apoptosis. Single\u2010cell RNA sequencing (scRNA\u2010seq) of PAAD tissues revealed that coixenolide specifically expanded and activated cytotoxic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells within the TME of HFD mice. Further analysis identified distinct malignant epithelial cell clusters enriched in HFD tumors, characterized by high expression of\n                    <jats:italic>S100a8\/a9<\/jats:italic>\n                    and stemness potential. Coixenolide treatment significantly reduced these\n                    <jats:italic>S100a8\/a9<\/jats:italic>\n                    \u2010expressing tumor cell populations and suppressed\n                    <jats:italic>S100a8\/a9<\/jats:italic>\n                    protein expression and secretion. Cell\u2013cell communication analysis and functional assays revealed that tumor cell\u2010derived\n                    <jats:italic>S100a8\/a9<\/jats:italic>\n                    interacted with\n                    <jats:italic>Cd36<\/jats:italic>\n                    on CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. This interaction promoted CD36\u2010mediated fatty acid uptake, leading to lipid peroxidation, ferroptosis, and functional exhaustion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Coixenolide disrupted this axis by inhibiting tumor cell\n                    <jats:italic>S100a8\/a9<\/jats:italic>\n                    , thereby downregulating CD36 on CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, reducing lipid peroxidation and ferroptosis, and restoring CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell cytotoxicity. Genetic knockout (\n                    <jats:italic>S100a9<\/jats:italic>\n                    KO) of tumor cells mimicked coixenolide's effects, enhancing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell function and suppressing tumor growth in vivo, especially in HFD mice. Clinical data confirmed elevated S100A8\/A9 expression in human PAAD tumors correlated with poor survival, advanced stage, and higher histological grade, and scRNA\u2010seq of patient samples showed S100A8\/A9 expression in malignant ductal cells. Collectively, these results identify coixenolide as an immune\u2010metabolic modulator that attenuates obesity\u2010driven immunosuppression in PAAD at least in significant part through inhibition of the S100A8\/A9\u2010CD36 axis, with lipid peroxidation and ferroptosis of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells reduced. Other mechanisms potentially involving regulatory T cells warrant further investigation in the future. These findings suggest S100A8\/A9\u2010CD36\u2010mediated intercellular crosstalk as a therapeutically actionable immune\u2010metabolic vulnerability in obesity\u2010associated PAAD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515759","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:04:37Z","timestamp":1787670277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8\n                    <sup>+<\/sup>\n                    T Cells by Inhibiting S100A8\/A9\u2010CD36 Axis in Obesity\u2010Associated Pancreatic Adenocarcinoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8797-1373","authenticated-orcid":false,"given":"Kaidi","family":"Chen","sequence":"first","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Changhai Hospital Naval Medical University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Guangzhou University of Chinese Medicine  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewei","family":"Dai","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Qi","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Xu","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangbin","family":"Li","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangping","family":"Wu","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Peng","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"},{"name":"Academy of Chinese Medical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Mu","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshen","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Immunity and Inflammation National Clinical Research Center for Digestive Diseases Shanghai Institute of Pancreatic Diseases, Changhai Clinical Research Unit, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University \/ Changhai Hospital Naval Medical University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanming","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-9200","authenticated-orcid":false,"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Immunity and Inflammation National Clinical Research Center for Digestive Diseases Shanghai Institute of Pancreatic Diseases, Changhai Clinical Research Unit, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University \/ Changhai Hospital Naval Medical University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3782-0988","authenticated-orcid":false,"given":"Mancang","family":"Gu","sequence":"additional","affiliation":[{"name":"Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University Jinhua Zhejiang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"},{"name":"Academy of Chinese Medical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang People's Republic of China"},{"name":"Institute For Innovation in Modern Traditional Chinese Medicine The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010018\u20101120\u20109"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010003717"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102017\u2010314828"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31628"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"issue":"18","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased Survival in Pancreatic Cancer With Nab\u2010Paclitaxel plus Gemcitabine","volume":"369","author":"Von Hoff D. D.","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c13038"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150535"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u20100300\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111627"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676\u2010200401000\u201000023"},{"issue":"5","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1053\/j.gastro.2018.08.009","article-title":"Immune Cell and Stromal Signature Associated With Progression\u2010Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma","volume":"155","author":"Mahajan U. M.","year":"2018","journal-title":"Gastroenterology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.03.012"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u20100363\u20105"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146832"},{"issue":"3","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/foods10030566","article-title":"Increases of Lipophilic Antioxidants and Anticancer Activity of Coix Seed Fermented by Monascus Purpureus","volume":"10","author":"Zeng H.","year":"2021","journal-title":"Foods"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115814"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20109966\u201027\u201031"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.299.5604.188"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.15407"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8586596","article-title":"Kanglaite Injection Combined With Chemotherapy Versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients With Advanced Non\u2010Small\u2010Cell Lung Cancer: A Systematic Review and Meta\u2010Analysis","volume":"2020","author":"Wen J.","year":"2020","journal-title":"Evidence\u2010Based Complementary and Alternative Medicine: eCAM"},{"issue":"6","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","article-title":"Mesothelial Cell\u2010Derived Antigen\u2010Presenting Cancer\u2010Associated Fibroblasts Induce Expansion of Regulatory T Cells in Pancreatic Cancer","volume":"40","author":"Huang H.","year":"2022","journal-title":"Cancer Cell"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201019\u20100094"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa127"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357\u20102725(01)00046\u20102"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.24441"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010019\u20100195\u2010y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029151\u20105"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20791"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.100638"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.770472","article-title":"Role of RAGE and Its Ligands on Inflammatory Responses to Brain Tumors","volume":"15","author":"Otazu G. K.","year":"2021","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi001791k"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70966"},{"issue":"5","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36\u2010Mediated Ferroptosis Dampens Intratumoral CD8+ T Cell Effector Function and Impairs Their Antitumor Ability","volume":"33","author":"Ma X.","year":"2021","journal-title":"Cell Metabolism"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101592"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191920"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100221\u20105"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.013"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210042"},{"issue":"2","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ultsonch.2006.03.005","article-title":"Ultrasound Assisted Supercritical Fluid Extraction of Oil and Coixenolide From Adlay Seed","volume":"14","author":"Hu A. J.","year":"2007","journal-title":"Ultrasonics Sonochemistry"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2026.111231"},{"issue":"4","key":"e_1_2_11_48_1","first-page":"639","article-title":"Protein Biomarkers and Alternatively Methylated Cell\u2010Free DNA Detect Early Stage Pancreatic Cancer","volume":"73","author":"Ben\u2010Ami R.","year":"2024","journal-title":"Gut"},{"issue":"17","key":"e_1_2_11_49_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713382","article-title":"S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy","volume":"24","author":"Razmkhah F.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40348-023-00168-0","article-title":"A Novel Serum Calprotectin (MRP8\/14) Particle\u2010Enhanced Immuno\u2010Turbidimetric Assay (sCAL Turbo) Helps to Differentiate Systemic Juvenile Idiopathic Arthritis From Other Diseases in Routine Clinical Laboratory Settings","volume":"10","author":"Foell D.","year":"2023","journal-title":"Molecular and Cellular Pediatrics"},{"issue":"9","key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.7150\/thno.17138","article-title":"Visualization of Tumor\u2010Immune Interaction\u2014Target\u2010Specific Imaging of S100A8\/A9 Reveals Pre\u2010Metastatic Niche Establishment","volume":"7","author":"Eisenblaetter M.","year":"2017","journal-title":"Theranostics"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029498\u20109"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201004477\u2010y"},{"issue":"1","key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s42255-018-0001-z","article-title":"GIP Regulates Inflammation and Body Weight by Restraining Myeloid\u2010Cell\u2010Derived S100A8\/A9","volume":"1","author":"Mantelmacher F. D.","year":"2019","journal-title":"Nature Metabolism"},{"issue":"2","key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/cac2.12388","article-title":"Elevated Neutrophil Extracellular Traps by HBV\u2010Mediated S100A9\u2010TLR4\/RAGE\u2010ROS Cascade Facilitate the Growth and Metastasis of Hepatocellular Carcinoma","volume":"43","author":"Zhan X.","year":"2023","journal-title":"Cancer Communications"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215598"},{"issue":"21","key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1182\/bloodadvances.2021005938","article-title":"Bone Marrow Stroma Cells Promote Induction of a Chemoresistant and Prognostic Unfavorable S100A8\/A9high AML Cell Subset","volume":"6","author":"B\u00f6ttcher M.","year":"2022","journal-title":"Blood Advances"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3415"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.10.009"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.011"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010019\u20100589\u20105"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102795"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010020\u20100470\u20103"},{"issue":"4","key":"e_1_2_11_64_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming Growth Factor\u2010\u03b2 Signaling in Immunity and Cancer","volume":"50","author":"Batlle E.","year":"2019","journal-title":"Immunity"},{"issue":"6","key":"e_1_2_11_65_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cmet.2023.04.017","article-title":"Cancer\u2010Cell\u2010Derived Fumarate Suppresses the Anti\u2010Tumor Capacity of CD8+ T Cells in the Tumor Microenvironment","volume":"35","author":"Cheng J.","year":"2023","journal-title":"Cell Metabolism"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0249"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202515759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202515759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202515759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:04:41Z","timestamp":1787670281000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202515759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":66,"alternative-id":["10.1002\/advs.202515759"],"URL":"https:\/\/doi.org\/10.1002\/advs.202515759","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2025-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15759"}}