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Owing to its rapid spread and high death rate, monkeypox must be prevented and controlled immediately. An advanced early warning system for monkeypox prevention and control is provided through aggregation\u2010induced emission luminogen (AIEgen)\u2010active monitoring and precision photodynamic therapy (PDT). This system are developed by combining a sprayable AIE@LD with a commercial liquid dressing (LD) and a pyridine\u2010substituted benzothiadiazole derivative possessing AIEgen properties. In vivo tests revealed that 1 min of low\u2010power white light PDT at 5\u00a0mW\u00a0cm\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>2<\/jats:sup>\n                    promoted viral eradication and lesion healing within one week. The system comprises dual optical channels that incorporate smartphone image recognition software and a cloud platform, combining image analysis, data transmission, infection monitoring, and PDT to provide a comprehensive solution for detecting, monitoring, treating, and interrupting the transmission of monkeypox. This system can considerably reduce the medical burden of monkeypox epidemics and provide innovative ideas and technological assistance for intelligent prevention and management.\n                  <\/jats:p>","DOI":"10.1002\/advs.202515865","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:45:12Z","timestamp":1764935112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["AIEgen\u2010Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control"],"prefix":"10.1002","volume":"13","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Institute for Engineering Medicine Kunming Medical University  Kunming Yunnan 650500 P. R. China"},{"name":"School of inspection Ningxia Medical University  Yinchuan Ningxia 750004 P. R. 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