{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:15:50Z","timestamp":1790237750241,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373190"],"award-info":[{"award-number":["52373190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307064"],"award-info":[{"award-number":["22307064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302433"],"award-info":[{"award-number":["82302433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Despite numerous therapeutic strategies targeting specific programmed cell death pathways, effectively eliminating malignant colorectal cancer (CRC) remains a significant challenge. Disulfidptosis, a newly identified form of cell death, is characterized by rapid NADPH depletion and abnormal disulfide bond formation in cytoskeletal proteins in cells with high SLC7A11 expression under glucose starvation. Given the aberrant expression of SLC7A11 and the hypermetabolic phenotype of CRC cells, targeting the disulfidptosis pathway offers a promising therapeutic approach for CRC treatment. Here, we developed a binuclear ruthenium complex, RuSSRu, bridged by a disulfide bond, to effectively induce the disulfidptosis pathway in CRC cells. Under two\u2010photon excitation, RuSSRu generates reactive oxygen species (ROS), leading to lysosomal damage and initiating cellular escape mechanisms. Crucially, this process triggers a cascade of metabolic disruptions, including an accumulation of disulfide bonds and ROS\u2010induced NADPH depletion, ultimately resulting in cytoskeletal collapse and disulfidptosis. The synergistic interaction between disulfidptosis and lysosomal damage\u2010induced apoptosis amplified tumor cell death, unveiling a novel mechanism and a versatile therapeutic strategy platform for CRC management.<\/jats:p>","DOI":"10.1002\/advs.202516046","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:57:47Z","timestamp":1771271867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disulfide\u2010Bridged Ru Complex\u2013Mediated Photo\u2010Disulfidptosis for Colorectal Cancer Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Simeng","family":"He","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-8803","authenticated-orcid":false,"given":"Kang\u2010Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University  Jinan China"},{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0956-2777","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00841-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.11.040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00689-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00449-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01091-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.07.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01100-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-024-01989-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39401-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.798405"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07056-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023328119"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12640-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0496-x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10744"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01457-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01135"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31269-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.04.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00211"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/9783110470734-011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00095a045"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6679"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45072-x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202302711"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00757F"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104714"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1752497"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb2210"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19638-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02032"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35037710"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm103557h"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00861C"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39854-y"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130306"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202516046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202516046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202516046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:08:20Z","timestamp":1776193700000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202516046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":39,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202516046"],"URL":"https:\/\/doi.org\/10.1002\/advs.202516046","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"assertion":[{"value":"2025-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16046"}}