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Here, we show that silk ligature\u2010induced PD in rats leads to anxiety\/depression\u2010like behaviors and impaired hippocampal neurogenesis. These alterations were associated with elevated hippocampal levels of C\u2010reactive protein (CRP), derived predominantly from the periphery. Knockout of\n                    <jats:italic>Crp<\/jats:italic>\n                    attenuated these PD\u2010induced hippocampal impairments, largely through downregulation of bone morphogenetic protein 4 (\n                    <jats:italic>Bmp4<\/jats:italic>\n                    ). Single\u2010nucleus RNA sequencing (snRNA\u2010seq) analysis revealed that hippocampal\n                    <jats:italic>Bmp4<\/jats:italic>\n                    expression is predominantly expressed by oligodendrocyte precursor cells (OPCs). Subsequent analyses associated CRP deficiency with enhanced functional resilience of OPCs. Critically, inhibition of the CRP\u2010BMP4 axis restored the neuronal differentiation suppressed by PD and alleviated the associated behavioral abnormalities. These findings elucidate a novel pathway linking periodontal disease to central nervous system disorders and suggest the CRP\u2010BMP4 axis as a potential therapeutic target for preventing PD\u2010related neurological complications.\n                  <\/jats:p>","DOI":"10.1002\/advs.202516199","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:44:28Z","timestamp":1773747868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CRP Deficiency Rescues Periodontitis\u2010Induced Hippocampal Neurogenesis Impairment by Suppressing OPC\u2010Derived BMP4 Signaling in Rats"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-3130","authenticated-orcid":false,"given":"Lingjie","family":"Li","sequence":"first","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Stomatological Hospital of Chongqing 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